This section contains a list of significant research and review articles pertaining to pancreatic cancer. The 'Research article' category contains publications where molecular alterations at the miRNA, mRNA or protein level were described. The 'Review articles' category contains reviews that should be of broad interest to those working on the molecular biology of pancreatic cancer. If you would like your paper to be considered for listing in any of these two categories, please use 'Submit new articles' tab for us to consider your article for inclusion here. Please note that data from more than 1,000 published articles has been curated and included in this database although all of those articles are not listed in the 'Publications' section here.
Research articles Review articles
1. Naidoo, K., Jones, R., Dmitrovic, B., Wijesuriya, N., Kocher, H., Hart, I. R. and Crnogorac-Jurcevic, T.  Proteome of formalin-fixed paraffin-embedded pancreatic ductal adenocarcinoma and lymph node metastases. The Journal of Pathology. 2011. [PubMed]
2. Kosanam, H., Makawita, S., Judd, B., Newman, A. and Diamandis, E. P.  Mining the malignant ascites proteome for pancreatic cancer biomarkers. Proteomics. 2011. 11, 4551-4558. [PubMed]
3. Wang, Y., Kuramitsu, Y., Ueno, T., Suzuki, N., Yoshino, S., Iizuka, N., Zhang, X., Oka, M. and Nakamura, K.  Differential expression of up-regulated cofilin-1 and down-regulated cofilin-2 characteristic of pancreatic cancer tissues. Oncology Reports. 2011. 26, 1595-1599. [PubMed]
4. Wang, Y., Kuramitsu, Y., Yoshino, S., Takashima, M., Zhang, X., Ueno, T., Suzuki, N., Oka, M. and Nakamura, K.  Screening for serological biomarkers of pancreatic cancer by two-dimensional electrophoresis and liquid chromatography-tandem mass spectrometry. Oncology Reports. 2011. 26, 287-292. [PubMed]
5. Pan, S., Chen, R., Crispin, D. A., May, D., Stevens, T., McIntosh, M. W., Bronner, M. P., Ziogas, A., Anton-Culver, H. and Brentnall, T. A.  Protein alterations associated with pancreatic cancer and chronic pancreatitis found in human plasma using global quantitative proteomics profiling. Journal of Proteome Research. 2011. 10, 2359-2376. [PubMed]
6. Zhou, W., Capello, M., Fredolini, C., Piemonti, L., Liotta, L. A., Novelli, F. and Petricoin, E. F.  Proteomic analysis of pancreatic ductal adenocarcinoma cells reveals metabolic alterations. Journal of Proteome Research. 2011. 10, 1944-1952. [PubMed]
7. Matsubara, J., Honda, K., Ono, M., Tanaka, Y., Kobayashi, M., Jung, G., Yanagisawa, K., Sakuma, T., Nakamori, S., Sata, N., Nagai, H., Ioka, T., Okusaka, T., Kosuge, T., Tsuchida, A., Shimahara, M., Yasunami, Y., Chiba, T., Hirohashi, S. and Yamada, T.  Reduced plasma level of CXC chemokine ligand 7 in patients with pancreatic cancer. Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association For Cancer Research, Cosponsored By the American Society Of. 2011. 20, 160-171. [PubMed]
8. Shi, W., Meng, Z., Chen, Z., Luo, J. and Liu, L.  Proteome analysis of human pancreatic cancer cell lines with highly liver metastatic potential by antibody microarray. Molecular and Cellular Biochemistry. 2011. 347, 117-125. [PubMed]
9. Lv, S., Gao, J., Zhu, F., Li, Z., Gong, Y., Xu, G. and Ma, L.  Transthyretin, identified by proteomics, is overabundant in pancreatic juice from pancreatic carcinoma and originates from pancreatic islets. Diagnostic Cytopathology. 2011. 39, 875-881. [PubMed]
10. Kuramitsu, Y., Taba, K., Ryozawa, S., Yoshida, K., Zhang, X., Tanaka, T., Maehara, S., Maehara, Y., Sakaida, I. and Nakamura, K.  Identification of up- and down-regulated proteins in gemcitabine-resistant pancreatic cancer cells using two-dimensional gel electrophoresis and mass spectrometry. Anticancer Research. 2010. 30, 3367-3372. [PubMed]
11. Zapico-Muniz, E., Farre-Viladrich, A., Rico-Santana, N., Gonzalez-Sastre, F. and Mora-Brugues, J.  Standardized peptidome profiling of human serum for the detection of pancreatic cancer. Pancreas. 2010. 39, 1293-1298. [PubMed]
12. McKinney, K. Q., Lee, Y. Y., Choi, H. S., Groseclose, G., Iannitti, D. A., Martinie, J. B., Russo, M. W., Lundgren, D. H., Han, D. K., Bonkovsky, H. L. and Hwang, S. I.  Discovery of putative pancreatic cancer biomarkers using subcellular proteomics. Journal of Proteomics. 2011. 74, 79-88. [PubMed]
13. Xue, A., Scarlett, C. J., Chung, L., Butturini, G., Scarpa, A., Gandy, R., Wilson, S. R., Baxter, R. C. and Smith, R. C.  Discovery of serum biomarkers for pancreatic adenocarcinoma using proteomic analysis. British Journal of Cancer. 2010. 103, 391-400. [PubMed]
14. Rong, Y., Jin, D., Hou, C., Hu, J., Wu, W., Ni, X., Wang, D. and Lou, W.  Proteomics analysis of serum protein profiling in pancreatic cancer patients by DIGE: up-regulation of mannose-binding lectin 2 and myosin light chain kinase 2. BMC Gastroenterology. 2010. 10, 68. [PubMed]
15. Zhou, W., Capello, M., Fredolini, C., Piemonti, L., Liotta, L. A., Novelli, F. and Petricoin, E. F.  Mass spectrometry analysis of the post-translational modifications of alpha-enolase from pancreatic ductal adenocarcinoma cells. Journal of Proteome Research. 2010. 9, 2929-2936. [PubMed]
16. Schroder, C., Jacob, A., Tonack, S., Radon, T. P., Sill, M., Zucknick, M., Ruffer, S., Costello, E., Neoptolemos, J. P., Crnogorac-Jurcevic, T., Bauer, A., Fellenberg, K. and Hoheisel, J. D.  Dual-color proteomic profiling of complex samples with a microarray of 810 cancer-related antibodies. Molecular & Cellular Proteomics : MCP. 2010. 9, 1271-1280. [PubMed]
17. Xiao, J., Lee, W. N., Zhao, Y., Cao, R., Go, V. L., Recker, R. R., Wang, Q. and Xiao, G. G.  Profiling pancreatic cancer-secreted proteome using 15N amino acids and serum-free media. Pancreas. 2010. 39, e17-23. [PubMed]
18. Guo, J., Wang, W., Liao, P., Lou, W., Ji, Y., Zhang, C., Wu, J. and Zhang, S.  Identification of serum biomarkers for pancreatic adenocarcinoma by proteomic analysis. Cancer Science. 2009. 100, 2292-2301. [PubMed]
19. Antwi, K., Hanavan, P. D., Myers, C. E., Ruiz, Y. W., Thompson, E. J. and Lake, D. F.  Proteomic identification of an MHC-binding peptidome from pancreas and breast cancer cell lines. Molecular Immunology. 2009. 46, 2931-2937. [PubMed]
20. Patwa, T. H., Li, C., Poisson, L. M., Kim, H. Y., Pal, M., Ghosh, D., Simeone, D. M. and Lubman, D. M.  The identification of phosphoglycerate kinase-1 and histone H4 autoantibodies in pancreatic cancer patient serum using a natural protein microarray. Electrophoresis. 2009. 30, 2215-2226. [PubMed]
21. Cui, Y., Zhang, D., Jia, Q., Li, T., Zhang, W. and Han, J.  Proteomic and tissue array profiling identifies elevated hypoxia-regulated proteins in pancreatic ductal adenocarcinoma. Cancer Investigation. 2009. 27, 747-755. [PubMed]
22. Fiedler, G. M., Leichtle, A. B., Kase, J., Baumann, S., Ceglarek, U., Felix, K., Conrad, T., Witzigmann, H., Weimann, A., Schutte, C., Hauss, J., Buchler, M. and Thiery, J.  Serum peptidome profiling revealed platelet factor 4 as a potential discriminating Peptide associated with pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2009. 15, 3812-3819. [PubMed]
23. Navaglia, F., Fogar, P., Basso, D., Greco, E., Padoan, A., Tonidandel, L., Fadi, E., Zambon, C. F., Bozzato, D., Moz, S., Seraglia, R., Pedrazzoli, S. and Plebani, M.  Pancreatic cancer biomarkers discovery by surface-enhanced laser desorption and ionization time-of-flight mass spectrometry. Clinical Chemistry and Laboratory Medicine : CCLM / FESCC. 2009. 47, 713-723. [PubMed]
24. Pan, S., Chen, R., Reimel, B. A., Crispin, D. A., Mirzaei, H., Cooke, K., Coleman, J. F., Lane, Z., Bronner, M. P., Goodlett, D. R., McIntosh, M. W., Traverso, W., Aebersold, R. and Brentnall, T. A.  Quantitative proteomics investigation of pancreatic intraepithelial neoplasia. Electrophoresis. 2009. 30, 1132-1144. [PubMed]
25. Chen, J. H., Ni, R. Z., Xiao, M. B., Guo, J. G. and Zhou, J. W.  Comparative proteomic analysis of differentially expressed proteins in human pancreatic cancer tissue. Hepatobiliary & Pancreatic Diseases International : HBPD INT. 2009. 8, 193-200. [PubMed]
26. Cui, Y., Wu, J., Zong, M., Song, G., Jia, Q., Jiang, J. and Han, J.  Proteomic profiling in pancreatic cancer with and without lymph node metastasis. International Journal of Cancer. Journal International Du Cancer. 2009. 124, 1614-1621. [PubMed]
27. Ke, E., Patel, B. B., Liu, T., Li, X. M., Haluszka, O., Hoffman, J. P., Ehya, H., Young, N. A., Watson, J. C., Weinberg, D. S., Nguyen, M. T., Cohen, S. J., Meropol, N. J., Litwin, S., Tokar, J. L. and Yeung, A. T.  Proteomic analyses of pancreatic cyst fluids. Pancreas. 2009. 38, e33-42. [PubMed]
28. Cui, Y., Tian, M., Zong, M., Teng, M., Chen, Y., Lu, J., Jiang, J., Liu, X. and Han, J.  Proteomic analysis of pancreatic ductal adenocarcinoma compared with normal adjacent pancreatic tissue and pancreatic benign cystadenoma. Pancreatology : Official Journal of the International Association of Pancreatology . 2009. 9, 89-98. [PubMed]
29. Zhao, Y., Lee, W. N., Lim, S., Go, V. L., Xiao, J., Cao, R., Zhang, H., Recker, R. R. and Xiao, G. G.  Quantitative proteomics: measuring protein synthesis using 15N amino acid labeling in pancreatic cancer cells. Analytical Chemistry. 2009. 81, 764-771. [PubMed]
30. Cheung, W., Darfler, M. M., Alvarez, H., Hood, B. L., Conrads, T. P., Habbe, N., Krizman, D. B., Mollenhauer, J., Feldmann, G. and Maitra, A.  Application of a global proteomic approach to archival precursor lesions: deleted in malignant brain tumors 1 and tissue transglutaminase 2 are upregulated in pancreatic cancer precursors. Pancreatology : Official Journal of the International Association of Pancreatology . 2008. 8, 608-616. [PubMed]
31. Kojima, K., Asmellash, S., Klug, C. A., Grizzle, W. E., Mobley, J. A. and Christein, J. D.  Applying proteomic-based biomarker tools for the accurate diagnosis of pancreatic cancer. Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract. 2008. 12, 1683-1690. [PubMed]
32. Tian, M., Cui, Y. Z., Song, G. H., Zong, M. J., Zhou, X. Y., Chen, Y. and Han, J. X.  Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients. BMC Cancer. 2008. 8, 241. [PubMed]
33. Chen, R., Pan, S., Aebersold, R. and Brentnall, T. A.  Proteomics studies of pancreatic cancer. Proteomics. Clinical Applications. 2007. 1, 1582-1591. [PubMed]
34. Ingvarsson, J., Wingren, C., Carlsson, A., Ellmark, P., Wahren, B., Engstrom, G., Harmenberg, U., Krogh, M., Peterson, C. and Borrebaeck, C. A.  Detection of pancreatic cancer using antibody microarray-based serum protein profiling. Proteomics. 2008. 8, 2211-2219. [PubMed]
35. Mori-Iwamoto, S., Kuramitsu, Y., Ryozawa, S., Taba, K., Fujimoto, M., Okita, K., Nakamura, K. and Sakaida, I.  A proteomic profiling of gemcitabine resistance in pancreatic cancer cell lines. Molecular Medicine Reports. 2008. 1, 429-434. [PubMed]
36. Chung, J. C., Oh, M. J., Choi, S. H. and Bae, C. D.  Proteomic analysis to identify biomarker proteins in pancreatic ductal adenocarcinoma. ANZ Journal of Surgery. 2008. 78, 245-251. [PubMed]
37. Tomaino, B., Cappello, P., Capello, M., Fredolini, C., Ponzetto, A., Novarino, A., Ciuffreda, L., Bertetto, O., De, A., Gaia, E., Salacone, P., Milella, M., Nistico, P., Alessio, M., Chiarle, R., Giuffrida, M. G., Giovarelli, M. and Novelli, F.  Autoantibody signature in human ductal pancreatic adenocarcinoma. Journal of Proteome Research. 2007. 6, 4025-4031. [PubMed]
38. Sun, Z. L., Zhu, Y., Wang, F. Q., Chen, R., Peng, T., Fan, Z. N., Xu, Z. K. and Miao, Y.  Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers. Biochimica et Biophysica Acta. 2007. 1774, 764-771. [PubMed]
39. Chen, R., Brentnall, T. A., Pan, S., Cooke, K., Moyes, K. W., Lane, Z., Crispin, D. A., Goodlett, D. R., Aebersold, R. and Bronner, M. P.  Quantitative proteomics analysis reveals that proteins differentially expressed in chronic pancreatitis are also frequently involved in pancreatic cancer. Molecular & Cellular Proteomics : MCP. 2007. 6, 1331-1342. [PubMed]
40. Zhou, L., Lu, Z., Yang, A., Deng, R., Mai, C., Sang, X., Faber, K. N. and Lu, X.  Comparative proteomic analysis of human pancreatic juice: methodological study. Proteomics. 2007. 7, 1345-1355. [PubMed]
41. Cecconi, D., Donadelli, M., Rinalducci, S., Zolla, L., Scupoli, M. T., Scarpa, A., Palmieri, M. and Righetti, P. G.  Proteomic analysis of pancreatic endocrine tumor cell lines treated with the histone deacetylase inhibitor trichostatin A. Proteomics. 2007. 7, 1644-1653. [PubMed]
42. Deng, R., Lu, Z., Chen, Y., Zhou, L. and Lu, X.  Plasma proteomic analysis of pancreatic cancer by 2-dimensional gel electrophoresis. Pancreas. 2007. 34, 310-317. [PubMed]
43. Qi, T., Han, J., Cui, Y., Zong, M., Liu, X. and Zhu, B.  Comparative proteomic analysis for the detection of biomarkers in pancreatic ductal adenocarcinomas. Journal of Clinical Pathology. 2008. 61, 49-58. [PubMed]
44. Mikuriya, K., Kuramitsu, Y., Ryozawa, S., Fujimoto, M., Mori, S., Oka, M., Hamano, K., Okita, K., Sakaida, I. and Nakamura, K.  Expression of glycolytic enzymes is increased in pancreatic cancerous tissues as evidenced by proteomic profiling by two-dimensional electrophoresis and liquid chromatography-mass spectrometry/mass spectrometry. International Journal of Oncology. 2007. 30, 849-855. [PubMed]
45. Kakisaka, T., Kondo, T., Okano, T., Fujii, K., Honda, K., Endo, M., Tsuchida, A., Aoki, T., Itoi, T., Moriyasu, F., Yamada, T., Kato, H., Nishimura, T., Todo, S. and Hirohashi, S.  Plasma proteomics of pancreatic cancer patients by multi-dimensional liquid chromatography and two-dimensional difference gel electrophoresis (2D-DIGE): up-regulation of leucine-rich alpha-2-glycoprotein in pancreatic cancer. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 2007. 852, 257-267. [PubMed]
46. Zhao, J., Qiu, W., Simeone, D. M. and Lubman, D. M.  N-linked glycosylation profiling of pancreatic cancer serum using capillary liquid phase separation coupled with mass spectrometric analysis. Journal of Proteome Research. 2007. 6, 1126-1138. [PubMed]
47. Chen, R., Pan, S., Cooke, K., Moyes, K. W., Bronner, M. P., Goodlett, D. R., Aebersold, R. and Brentnall, T. A.  Comparison of pancreas juice proteins from cancer versus pancreatitis using quantitative proteomic analysis. Pancreas. 2007. 34, 70-79. [PubMed]
48. Lin, Y., Goedegebuure, P. S., Tan, M. C., Gross, J., Malone, J. P., Feng, S., Larson, J., Phommaly, C., Trinkaus, K., Townsend, R. R. and Linehan, D. C.  Proteins associated with disease and clinical course in pancreas cancer: a proteomic analysis of plasma in surgical patients. Journal of Proteome Research. 2006. 5, 2169-2176. [PubMed]
49. Zhao, J., Simeone, D. M., Heidt, D., Anderson, M. A. and Lubman, D. M.  Comparative serum glycoproteomics using lectin selected sialic acid glycoproteins with mass spectrometric analysis: application to pancreatic cancer serum. Journal of Proteome Research. 2006. 5, 1792-1802. [PubMed]
50. Chen, R., Pan, S., Yi, E. C., Donohoe, S., Bronner, M. P., Potter, J. D., Goodlett, D. R., Aebersold, R. and Brentnall, T. A.  Quantitative proteomic profiling of pancreatic cancer juice. Proteomics. 2006. 6, 3871-3879. [PubMed]
51. Scarlett, C. J., Smith, R. C., Saxby, A., Nielsen, A., Samra, J. S., Wilson, S. R. and Baxter, R. C.  Proteomic classification of pancreatic adenocarcinoma tissue using protein chip technology. Gastroenterology. 2006. 130, 1670-1678. [PubMed]
52. Roda, O., Chiva, C., Espuna, G., Gabius, H. J., Real, F. X., Navarro, P. and Andreu, D.  A proteomic approach to the identification of new tPA receptors in pancreatic cancer cells. Proteomics. 2006. 6 Suppl 1, S36-41. [PubMed]
53. Bloomston, M., Zhou, J. X., Rosemurgy, A. S., Frankel, W., Muro-Cacho, C. A. and Yeatman, T. J.  Fibrinogen gamma overexpression in pancreatic cancer identified by large-scale proteomic analysis of serum samples. Cancer Research. 2006. 66, 2592-2599. [PubMed]
54. Hwang, T. L., Liang, Y., Chien, K. Y. and Yu, J. S.  Overexpression and elevated serum levels of phosphoglycerate kinase 1 in pancreatic ductal adenocarcinoma. Proteomics. 2006. 6, 2259-2272. [PubMed]
55. Cecconi, D., Donadelli, M., Scarpa, A., Milli, A., Palmieri, M., Hamdan, M., Areces, L. B., Rappsilber, J. and Righetti, P. G.  Proteomic analysis of pancreatic ductal carcinoma cells after combined treatment with gemcitabine and trichostatin A. Journal of Proteome Research. 2005. 4, 1909-1916. [PubMed]
56. Honda, K., Hayashida, Y., Umaki, T., Okusaka, T., Kosuge, T., Kikuchi, S., Endo, M., Tsuchida, A., Aoki, T., Itoi, T., Moriyasu, F., Hirohashi, S. and Yamada, T.  Possible detection of pancreatic cancer by plasma protein profiling. Cancer Research. 2005. 65, 10613-10622. [PubMed]
57. Crnogorac-Jurcevic, T., Gangeswaran, R., Bhakta, V., Capurso, G., Lattimore, S., Akada, M., Sunamura, M., Prime, W., Campbell, F., Brentnall, T. A., Costello, E., Neoptolemos, J. and Lemoine, N. R.  Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma. Gastroenterology. 2005. 129, 1454-1463. [PubMed]
58. Chen, R., Yi, E. C., Donohoe, S., Pan, S., Eng, J., Cooke, K., Crispin, D. A., Lane, Z., Goodlett, D. R., Bronner, M. P., Aebersold, R. and Brentnall, T. A.  Pancreatic cancer proteome: the proteins that underlie invasion, metastasis, and immunologic escape. Gastroenterology. 2005. 129, 1187-1197. [PubMed]
59. Gronborg, M., Kristiansen, T. Z., Iwahori, A., Chang, R., Reddy, R., Sato, N., Molina, H., Jensen, O. N., Hruban, R. H., Goggins, M. G., Maitra, A. and Pandey, A.  Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. Molecular & Cellular Proteomics : MCP. 2006. 5, 157-171. [PubMed]
60. Yu, K. H., Rustgi, A. K. and Blair, I. A.  Characterization of proteins in human pancreatic cancer serum using differential gel electrophoresis and tandem mass spectrometry. Journal of Proteome Research. 2005. 4, 1742-1751. [PubMed]
61. Sitek, B., Luttges, J., Marcus, K., Kloppel, G., Schmiegel, W., Meyer, H. E., Hahn, S. A. and Stuhler, K.  Application of fluorescence difference gel electrophoresis saturation labelling for the analysis of microdissected precursor lesions of pancreatic ductal adenocarcinoma. Proteomics. 2005. 5, 2665-2679. [PubMed]
62. Xia, Q., Kong, X. T., Zhang, G. A., Hou, X. J., Qiang, H. and Zhong, R. Q.  Proteomics-based identification of DEAD-box protein 48 as a novel autoantigen, a prospective serum marker for pancreatic cancer. Biochemical and Biophysical Research Communications. 2005. 330, 526-532. [PubMed]
63. Bhattacharyya, S., Siegel, E. R., Petersen, G. M., Chari, S. T., Suva, L. J. and Haun, R. S.  Diagnosis of pancreatic cancer using serum proteomic profiling. Neoplasia. 2004. 6, 674-686. [PubMed]
64. Rosty, C. and Goggins, M.  Identification of differentially expressed proteins in pancreatic cancer using a global proteomic approach. Methods in Molecular Medicine. 2005. 103, 189-197. [PubMed]
65. Lu, Z., Hu, L., Evers, S., Chen, J. and Shen, Y.  Differential expression profiling of human pancreatic adenocarcinoma and healthy pancreatic tissue. Proteomics. 2004. 4, 3975-3988. [PubMed]
66. Gronborg, M., Bunkenborg, J., Kristiansen, T. Z., Jensen, O. N., Yeo, C. J., Hruban, R. H., Maitra, A., Goggins, M. G. and Pandey, A.  Comprehensive proteomic analysis of human pancreatic juice. Journal of Proteome Research. 2004. 3, 1042-1055. [PubMed]
67. Hong, S. H., Misek, D. E., Wang, H., Puravs, E., Giordano, T. J., Greenson, J. K., Brenner, D. E., Simeone, D. M., Logsdon, C. D. and Hanash, S. M.  An autoantibody-mediated immune response to calreticulin isoforms in pancreatic cancer. Cancer Research. 2004. 64, 5504-5510. [PubMed]
68. Marengo, E., Robotti, E., Cecconi, D., Hamdan, M., Scarpa, A. and Righetti, P. G.  Identification of the regulatory proteins in human pancreatic cancers treated with Trichostatin A by 2D-PAGE maps and multivariate statistical analysis. Analytical and Bioanalytical Chemistry. 2004. 379, 992-1003. [PubMed]
69. Cecconi, D., Astner, H., Donadelli, M., Palmieri, M., Missiaglia, E., Hamdan, M., Scarpa, A. and Righetti, P. G.  Proteomic analysis of pancreatic ductal carcinoma cells treated with 5-aza-2'-deoxycytidine. Electrophoresis. 2003. 24, 4291-4303. [PubMed]
70. Shekouh, A. R., Thompson, C. C., Prime, W., Campbell, F., Hamlett, J., Herrington, C. S., Lemoine, N. R., Crnogorac-Jurcevic, T., Buechler, M. W., Friess, H., Neoptolemos, J. P., Pennington, S. R. and Costello, E.  Application of laser capture microdissection combined with two-dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinoma. Proteomics. 2003. 3, 1988-2001. [PubMed]
71. Cecconi, D., Scarpa, A., Donadelli, M., Palmieri, M., Hamdan, M., Astner, H. and Righetti, P. G.  Proteomic profiling of pancreatic ductal carcinoma cell lines treated with trichostatin-A. Electrophoresis. 2003. 24, 1871-1878. [PubMed]
72. Moller, A., Malerczyk, C., Volker, U., Stoppler, H. and Maser, E.  Monitoring daunorubicin-induced alterations in protein expression in pancreas carcinoma cells by two-dimensional gel electrophoresis. Proteomics. 2002. 2, 697-705. [PubMed]
73. Jamieson, N. B., Morran, D. C., Morton, J. P., Ali, A., Dickson, E. J., Carter, R., Sansom, O. J., Evans, T., McKay, C. J. and Oien, K. A.  MicroRNA molecular profiles associated with diagnosis, clinicopathological criteria, and overall survival in patients with resectable pancreatic ductal adenocarcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2011. [PubMed]
74. Yu, J., Li, A., Hong, S. M., Hruban, R. H. and Goggins, M.  MicroRNA Alterations of Pancreatic Intraepithelial Neoplasms (PanINs). Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2011. [PubMed]
75. Jung, D. E., Wen, J., Oh, T. and Song, S. Y.  Differentially expressed microRNAs in pancreatic cancer stem cells. Pancreas. 2011. 40, 1180-1187. [PubMed]
76. Baine, M. J., Chakraborty, S., Smith, L. M., Mallya, K., Sasson, A. R., Brand, R. E. and Batra, S. K.  Transcriptional profiling of peripheral blood mononuclear cells in pancreatic cancer patients identifies novel genes with potential diagnostic utility. PloS One. 2011. 6, e17014. [PubMed]
77. Li, C., Kim, H. Y., Vuong, H., Patwa, T., Pal, M., Brand, R. E., Simeone, D. M. and Lubman, D. M.  The identification of auto-antibodies in pancreatic cancer patient sera using a naturally fractionated Panc-1 cell line. Cancer Biomarkers : Section A of Disease Markers. 2010. 7, 25-37. [PubMed]
78. Shi, W., Meng, Z., Chen, Z., Luo, J. and Liu, L.  Proteome analysis of human pancreatic cancer cell lines with highly liver metastatic potential by antibody microarray. Molecular and Cellular Biochemistry. 2011. 347, 117-125. [PubMed]
79. Morse, D. L., Balagurunathan, Y., Hostetter, G., Trissal, M., Tafreshi, N. K., Burke, N., Lloyd, M., Enkemann, S., Coppola, D., Hruby, V. J., Gillies, R. J. and Han, H.  Identification of novel pancreatic adenocarcinoma cell-surface targets by gene expression profiling and tissue microarray. Biochemical Pharmacology. 2010. 80, 748-754. [PubMed]
80. Mees, S. T., Schleicher, C., Mardin, W. A., Senninger, N., Colombo-Benkmann, M. and Haier, J.  Analyzing miRNAs in ductal adenocarcinomas of the pancreas. The Journal of Surgical Research. 2011. 169, 241-246. [PubMed]
81. Olakowski, M., Tyszkiewicz, T., Jarzab, M., Krol, R., Oczko-Wojciechowska, M., Kowalska, M., Kowal, M., Gala, G. M., Kajor, M., Lange, D., Chmielik, E., Gubala, E., Lampe, P. and Jarzab, B.  NBL1 and anillin (ANLN) genes over-expression in pancreatic carcinoma. Folia Histochemica et Cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society. 2009. 47, 249-255. [PubMed]
82. Zhang, L., Farrell, J. J., Zhou, H., Elashoff, D., Akin, D., Park, N. H., Chia, D. and Wong, D. T.  Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer. Gastroenterology. 2010. 138, 949-1519. [PubMed]
83. Hirono, S., Yamaue, H., Hoshikawa, Y., Ina, S., Tani, M., Kawai, M., Ushijima, M., Matsuura, M., Saiki, Y., Saiura, A., Yamamoto, J., Miki, Y. and Noda, T.  Molecular markers associated with lymph node metastasis in pancreatic ductal adenocarcinoma by genome-wide expression profiling. Cancer Science. 2010. 101, 259-266. [PubMed]
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85. Ingvarsson, J., Wingren, C., Carlsson, A., Ellmark, P., Wahren, B., Engstrom, G., Harmenberg, U., Krogh, M., Peterson, C. and Borrebaeck, C. A.  Detection of pancreatic cancer using antibody microarray-based serum protein profiling. Proteomics. 2008. 8, 2211-2219. [PubMed]
86. Zhao, Y. P., Chen, G., Feng, B., Zhang, T. P., Ma, E. L. and Wu, Y. D.  Microarray analysis of gene expression profile of multidrug resistance in pancreatic cancer. Chinese Medical Journal. 2007. 120, 1743-1752. [PubMed]
87. Rogers, C. D., Fukushima, N., Sato, N., Shi, C., Prasad, N., Hustinx, S. R., Matsubayashi, H., Canto, M., Eshleman, J. R., Hruban, R. H. and Goggins, M.  Differentiating pancreatic lesions by microarray and QPCR analysis of pancreatic juice RNAs. Cancer Biology & Therapy. 2006. 5, 1383-1389. [PubMed]
88. Johnson, S. K., Dennis, R. A., Barone, G. W., Lamps, L. W. and Haun, R. S.  Differential expression of insulin-like growth factor binding protein-5 in pancreatic adenocarcinomas: identification using DNA microarray. Molecular Carcinogenesis. 2006. 45, 814-827. [PubMed]
89. Xu, L., Li, Y. M., Yu, C. H., Li, L., Liu, Y. S., Zhang, B. F., Fang, J., Zhou, Q., Hu, Y. and Gao, H. J.  Expression of p53, p16 and COX-2 in pancreatic cancer with tissue microarray. Hepatobiliary & Pancreatic Diseases International : HBPD INT. 2006. 5, 138-142. [PubMed]
90. Jin, G., Hu, X. G., Ying, K., Tang, Y., Liu, R., Zhang, Y. J., Jing, Z. P., Xie, Y. and Mao, Y. M.  Discovery and analysis of pancreatic adenocarcinoma genes using cDNA microarrays. World Journal of Gastroenterology : WJG. 2005. 11, 6543-6548. [PubMed]
91. Orchekowski, R., Hamelinck, D., Li, L., Gliwa, E., vanBrocklin, M., Marrero, J. A., Vande, W., Feng, Z., Brand, R. and Haab, B. B.  Antibody microarray profiling reveals individual and combined serum proteins associated with pancreatic cancer. Cancer Research. 2005. 65, 11193-11202. [PubMed]
92. Chen, R., Yi, E. C., Donohoe, S., Pan, S., Eng, J., Cooke, K., Crispin, D. A., Lane, Z., Goodlett, D. R., Bronner, M. P., Aebersold, R. and Brentnall, T. A.  Pancreatic cancer proteome: the proteins that underlie invasion, metastasis, and immunologic escape. Gastroenterology. 2005. 129, 1187-1197. [PubMed]
93. Misek, D. E., Kuick, R., Hanash, S. M. and Logsdon, C. D.  Oligonucleotide-directed microarray gene profiling of pancreatic adenocarcinoma. Methods in Molecular Medicine. 2005. 103, 175-187. [PubMed]
94. Durkin, A. J., Bloomston, M., Yeatman, T. J., Gilbert-Barness, E., Cojita, D., Rosemurgy, A. S. and Zervos, E. E.  Differential expression of the Tie-2 receptor and its ligands in human pancreatic tumors. Journal of the American College of Surgeons. 2004. 199, 724-731. [PubMed]
95. Cao, D., Hustinx, S. R., Sui, G., Bala, P., Sato, N., Martin, S., Maitra, A., Murphy, K. M., Cameron, J. L., Yeo, C. J., Kern, S. E., Goggins, M., Pandey, A. and Hruban, R. H.  Identification of novel highly expressed genes in pancreatic ductal adenocarcinomas through a bioinformatics analysis of expressed sequence tags. Cancer Biology & Therapy. 2004. 3, 1081-1090. [PubMed]
96. Missiaglia, E., Blaveri, E., Terris, B., Wang, Y. H., Costello, E., Neoptolemos, J. P., Crnogorac-Jurcevic, T. and Lemoine, N. R.  Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis. International Journal of Cancer. Journal International Du Cancer. 2004. 112, 100-112. [PubMed]
97. Nakamura, T., Furukawa, Y., Nakagawa, H., Tsunoda, T., Ohigashi, H., Murata, K., Ishikawa, O., Ohgaki, K., Kashimura, N., Miyamoto, M., Hirano, S., Kondo, S., Katoh, H., Nakamura, Y. and Katagiri, T.  Genome-wide cDNA microarray analysis of gene expression profiles in pancreatic cancers using populations of tumor cells and normal ductal epithelial cells selected for purity by laser microdissection. Oncogene. 2004. 23, 2385-2400. [PubMed]
98. Maitra, A., Hansel, D. E., Argani, P., Ashfaq, R., Rahman, A., Naji, A., Deng, S., Geradts, J., Hawthorne, L., House, M. G. and Yeo, C. J.  Global expression analysis of well-differentiated pancreatic endocrine neoplasms using oligonucleotide microarrays. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 2003. 9, 5988-5995. [PubMed]
99. Yu, X. J., Long, J., Fu, D. L., Zhang, Q. H. and Ni, Q. X.  Analysis of gene expression profiles in pancreatic carcinoma by using cDNA microarray. Hepatobiliary & Pancreatic Diseases International : HBPD INT. 2003. 2, 467-470. [PubMed]
100. Grutzmann, R., Foerder, M., Alldinger, I., Staub, E., Brummendorf, T., Ropcke, S., Li, X., Kristiansen, G., Jesnowski, R., Sipos, B., Lohr, M., Luttges, J., Ockert, D., Kloppel, G., Saeger, H. D. and Pilarsky, C.  Gene expression profiles of microdissected pancreatic ductal adenocarcinoma. Virchows Archiv : An International Journal of Pathology. 2003. 443, 508-517. [PubMed]
101. Tanaka, H., Hata, F., Nishimori, H., Honmou, O., Yasoshima, T., Nomura, H., Ohno, K., Hirai, I., Kamiguchi, K., Isomura, H., Hirohashi, Y., Denno, R., Sato, N. and Hirata, K.  Differential gene expression screening between parental and highly metastatic pancreatic cancer variants using a DNA microarray. Journal of Experimental & Clinical Cancer Research : CR. 2003. 22, 307-313. [PubMed]
102. Friess, H., Ding, J., Kleeff, J., Fenkell, L., Rosinski, J. A., Guweidhi, A., Reidhaar-Olson, J. F., Korc, M., Hammer, J. and Buchler, M. W.  Microarray-based identification of differentially expressed growth- and metastasis-associated genes in pancreatic cancer. Cellular and Molecular Life Sciences : CMLS. 2003. 60, 1180-1199. [PubMed]
103. Logsdon, C. D., Simeone, D. M., Binkley, C., Arumugam, T., Greenson, J. K., Giordano, T. J., Misek, D. E., Kuick, R. and Hanash, S.  Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. Cancer Research. 2003. 63, 2649-2657. [PubMed]
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105. Maitra, A., Iacobuzio-Donahue, C., Rahman, A., Sohn, T. A., Argani, P., Meyer, R., Yeo, C. J., Cameron, J. L., Goggins, M., Kern, S. E., Ashfaq, R., Hruban, R. H. and Wilentz, R. E.  Immunohistochemical validation of a novel epithelial and a novel stromal marker of pancreatic ductal adenocarcinoma identified by global expression microarrays: sea urchin fascin homolog and heat shock protein 47. American Journal of Clinical Pathology. 2002. 118, 52-59. [PubMed]
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Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."