Matrix metallopeptidase 12 (macrophage elastase)
Gene Symbol   MMP12 Chromosome Locus   11q22.3
 
  Alternate Names    
     
 
Macrophage elastase; MME; Macrophage Metalloelastase
 
   
 
  RNA Alterations     
     
 
Cancer Type
Experiment Type
Expression Level
Fold Change
PubMed ID
Invasive ductal adenocarcinoma DNA microarray
Increased
5.4
Lowe et al. 2007
Invasive ductal adenocarcinoma DNA microarray
Increased
45.5
Friess et al. 2003
Cell Line
Experiment Type
Expression Level
Fold Change
PubMed ID
T3M4 RT-PCR
Increased
Balaz et al. 2002
ASPC-1 RT-PCR
Increased
Balaz et al. 2002
CAPAN-1 RT-PCR
Increased
Balaz et al. 2002
PANC-1 RT-PCR
Increased
Balaz et al. 2002
MIA-PaCa-2 RT-PCR
Increased
Balaz et al. 2002
 
   
 
  Protein Alterations     
     
 
Cancer Type
Experiment Type
Expression Level
Fold Change
PubMed ID
Invasive ductal adenocarcinoma Immunohistochemistry
Increased
Balaz et al.
Invasive ductal adenocarcinoma Western blot
Increased
4.7
 Balaz et al.
Cell Line
Experiment Type
Expression Level
Fold Change
PubMed ID
PANC-1 Western blot
Increased
Balaz et al. 2002
MiaPaCa-2 Western blot
Increased
Balaz et al. 2002
 
   
 
 Chronic Pancreatitis    
     
 
RNA/Protein
Experiment Type
Expression Level
Fold Change
PubMed ID
RNA DNA microarray
Increased
2.7
 Valkovskaya et al.
Protein Immunohistochemistry
Increased
Balaz et al.
Protein Immunohistochemistry
Increased
Balaz et al.
RNA Northern blot
Increased
Balaz et al. 2002
 
   
 
 
  Expressed in Body Fluid /Plasma Membrane  
     
 
     
 
Plasma Membrane -
Secreted - 
Body Fluid
-
 
   
 
   
 
  External Links     
     
 
HPRD
Entrez Gene
OMIM
HGNC
 
   
 
 
 
 

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."