Pancreatic Cancer Database

Lumican

Gene Symbol

LUM

Chromosome Locus

12q21.3-q22

Alternate Names

Keratan sulfate proteoglycan lumican; KSPG lumican

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Intraductal papillary mucinous neoplasms	DNA microarray	Increased	21.4	Sato et al. 2004
Intraductal papillary mucinous neoplasms	RT-PCR	Increased		Sato et al. 2004
Invasive ductal adenocarcinoma	DNA microarray	Increased	14.3	Friess et al. 2003
Invasive ductal adenocarcinoma	In situ hybridization	Increased		Ping et al. 2002
Invasive ductal adenocarcinoma	In situ hybridization	Increased		Ping et al. 2002
Invasive ductal adenocarcinoma	DNA microarray	Increased	3.5	Lowe et al. 2007
Invasive ductal adenocarcinoma	DNA microarray	Increased	6	Crnogorac-Jurcevic et al. 2003
Invasive ductal adenocarcinoma	SAGE	Increased		Hustinx et al. 2004
Invasive ductal adenocarcinoma	DNA microarray	Increased	9.9	Jin et al. 2006
Invasive ductal adenocarcinoma	DNA microarray	Increased	5.2	Tan et al. 2003
Invasive ductal adenocarcinoma	RT-PCR	Increased	22	Koninger et al. 2004
PanIN-3	DNA microarray	Increased	2.8	Buchholz et al. 2005

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	ICAT	Increased	4.2	Chen et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Ping et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Ping et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Koninger et al.
Pancreatic ductal adenocarcinoma	Selected reaction monitoring	Increased		Pan et al. 2012
Pancreatic ductal adenocarcinoma	Immunohistochemistry	Increased		Yang et al. 2012
Invasive ductal adenocarcinoma	Label free quantitation, Mass spectrometry	Increased	13.1	Pan et al. 2011

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
RNA	DNA microarray	Increased	8.6	Friess et al.
RNA	DNA microarray	Increased	2	Binkley et al. 2004
Protein	Label free quantitation, Mass spectrometry	Increased	6.3	Pan et al. 2011
Protein	Label free quantitation, Mass spectrometry	Increased	12.8	Pan et al. 2011

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

Secreted

Body Fluid

Plasma

External Links

HPRD	Entrez Gene	OMIM	HGNC
02793	4060	600616	HGNC:6724