Pancreatic Cancer Database

S100 calcium binding protein A4

Gene Symbol

S100A4

Chromosome Locus

1q21

Alternate Names

Malignant transformation suppression 1; Calcium placental protein; Metastasin

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Intraductal papillary mucinous neoplasm with an associated invasive carcinoma	DNA microarray	Increased	80.7	Sato et al. 2004
Intraductal papillary mucinous neoplasms	RT-PCR	Increased		Sato et al. 2004
Intraductal papillary mucinous neoplasms	DNA microarray	Increased	24.4	Sato et al. 2004
Invasive ductal adenocarcinoma	SAGE	Increased		Hustinx et al. 2004
Invasive ductal adenocarcinoma	SAGE	Increased		Ryu et al. 2002
Invasive ductal adenocarcinoma	DNA microarray	Increased	3	Iacobuzio-Donahue et al. 2003
Invasive ductal adenocarcinoma	DNA microarray	Increased		Farrow et al. 2004
Invasive ductal adenocarcinoma	SAGE	Increased		Rosty et al. 2002

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
Panc-1	RT-PCR	Increased	2	Tabata et al.
BxPC-3	RT-PCR	Increased	2	Tabata et al.
MIA PaCa-2	RT-PCR	Increased	2	Tabata et al.
AsPC-1	RT-PCR	Increased	2	Tabata et al.
PK-1	RT-PCR	Increased	2	Tabata et al.
PK-8	RT-PCR	Increased	2	Tabata et al.
PK-9	RT-PCR	Increased	2	Tabata et al.
PK-45P	RT-PCR	Increased	2	Tabata et al.
PK-45H	RT-PCR	Increased	2	Tabata et al.
PK-59	RT-PCR	Increased	2	Tabata et al.
PCI-19	RT-PCR	Increased	2	Tabata et al.
PCI-24	RT-PCR	Increased	2	Tabata et al.
PCI-55	RT-PCR	Increased	2	Tabata et al.
PCI-64	RT-PCR	Increased	2	Tabata et al.
PCI-66	RT-PCR	Increased	2	Tabata et al.
PAN-03-JCK	RT-PCR	Increased	2	Tabata et al.
PAN-07-JCK	RT-PCR	Increased	2	Tabata et al.
PAN-08-JCK	RT-PCR	Increased	2	Tabata et al.
PAN-09-JCK. T	RT-PCR	Increased	2	Tabata et al.
AsPC1	RT-PCR	Increased		Rosty et al. 2002
BxPC3	RT-PCR	Increased		Rosty et al. 2002
CAPAN1	RT-PCR	Increased		Rosty et al. 2002
CAPAN2	RT-PCR	Increased		Rosty et al. 2002
CFPAC1	RT-PCR	Increased		Rosty et al. 2002
Hs766T	RT-PCR	Increased		Rosty et al. 2002
MiaPaca2	RT-PCR	Increased		Rosty et al. 2002
Panc1	RT-PCR	Increased		Rosty et al. 2002
PL1	RT-PCR	Increased		Rosty et al. 2002
PL2	RT-PCR	Increased		Rosty et al. 2002
PL3	RT-PCR	Increased		Rosty et al. 2002
PL4	RT-PCR	Increased		Rosty et al. 2002
PL5	RT-PCR	Increased		Rosty et al. 2002
PL6	RT-PCR	Increased		Rosty et al. 2002
PL8	RT-PCR	Increased		Rosty et al. 2002
PL9	RT-PCR	Increased		Rosty et al. 2002
PL10	RT-PCR	Increased		Rosty et al. 2002
PL11	RT-PCR	Increased		Rosty et al. 2002
PL14	RT-PCR	Increased		Rosty et al. 2002
CAPAN1	SAGE	Increased		Rosty et al. 2002
CAPAN2	SAGE	Increased		Rosty et al. 2002
Panc1	SAGE	Increased		Rosty et al. 2002
AsPc1	RT-PCR	Increased		Ryu et al. 2002
CAPAN1	RT-PCR	Increased		Ryu et al. 2002
CAPAN2	RT-PCR	Increased		Ryu et al. 2002
Panc-1	RT-PCR	Increased		Ryu et al. 2002
PL45	RT-PCR	Increased		Ryu et al. 2002
AsPc1	SAGE	Increased		Ryu et al. 2002
CAPAN1	SAGE	Increased		Ryu et al. 2002
CAPAN2	SAGE	Increased		Ryu et al. 2002
Panc-1	SAGE	Increased		Ryu et al. 2002
PL45	SAGE	Increased		Ryu et al. 2002
AsPC1	SAGE	Increased		Hustinx et al. 2004
PL11	SAGE	Increased		Hustinx et al. 2004
MiaPaCa2	SAGE	Increased		Hustinx et al. 2004
BXPC3	SAGE	Increased		Hustinx et al. 2004
CFPAC1	SAGE	Increased		Hustinx et al. 2004
PL13	SAGE	Increased		Hustinx et al. 2004
PL3	SAGE	Increased		Hustinx et al. 2004
CAPAN2	SAGE	Increased		Hustinx et al. 2004
PL6	SAGE	Increased		Hustinx et al. 2004
PL4	SAGE	Increased		Hustinx et al. 2004
Hs766T	SAGE	Increased		Hustinx et al. 2004
Panc1	SAGE	Increased		Hustinx et al. 2004
PL12	SAGE	Increased		Hustinx et al. 2004
Su8714	SAGE	Increased		Hustinx et al. 2004

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	SILAC, Tandem mass spectrometry	Increased	25.9	Yu et al.
Intraductal papillary mucinous neoplasms	Immunohistochemistry	Increased		Sato et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Rosty et al.
PanIN-3	Immunohistochemistry	Increased		Rosty et al.
Pancreatic ductal adenocarcinoma	Immunohistochemistry	Increased		Arumugam et al. 2012

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

Secreted

Body Fluid

External Links

HPRD	Entrez Gene	OMIM	HGNC
15914	6275	114210	HGNC:10494

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."