Pancreatic Cancer Database

Transforming growth factor-

Gene Symbol

TGFB1

Chromosome Locus

19q13.2;19q13.1

Alternate Names

TGF beta; TGFB; Transforming growth factor beta 1

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	Northern blot	Increased		Kleeff et al. 1999
Invasive ductal adenocarcinoma	RT-PCR	Increased		Bellone et al. 2005
Invasive ductal adenocarcinoma	DNA microarray	Increased	8.2	Friess et al. 2003
Invasive ductal adenocarcinoma	RT-PCR	Increased	3.4	Aoyagi et al. 2004
Invasive ductal adenocarcinoma	DNA microarray	Increased		Andrianifahanana et al. 2006
Intraductal papillary mucinous neoplasm with low-grade dysplasia	RT-PCR	Increased		Van et al. 1997
Intraductal papillary mucinous neoplasm with moderate dysplasia	RT-PCR	Increased		Van et al. 1997
Intraductal papillary mucinous neoplasm with an associated invasive c	RT-PCR	Increased		Van et al. 1997
Invasive ductal adenocarcinoma	DNA microarray	Increased	2.4	Van et al. 2012

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	ELISA	Increased		Bellone et al.
Invasive ductal adenocarcinoma	ICAT	Increased	2.5	Chen et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Kleeff et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Bergmann et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Bellone et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Zhang et al.
PanIN-1A	Immunohistochemistry	Increased		Ito et al.
PanIN-1B	Immunohistochemistry	Increased		Ito et al.
PanIN-2	Immunohistochemistry	Increased		Ito et al.
PanIN-3	Immunohistochemistry	Increased		Ito et al.
Pancreatic ductal adenocarcinoma	Antibody microarray	Increased		Kelber et al. 2012
Pancreatic cancer	Mass spectrometry	Increased	2.8	Gebauer et al. 2011

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
PANC-1	SILAC, Tandem mass spectrometry	Decreased		Gronborg et al.
PT-45	ELISA	Increased		Bellone et al. 2005
Capan-2	ELISA	Increased		Bellone et al. 2005
BxPC-3	ELISA	Increased		Bellone et al. 2005
PANC-1	ELISA	Increased		Bellone et al. 2005
MIAPaCa-2	ELISA	Increased		Bellone et al. 2005

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

Secreted

16215274

Body Fluid

External Links

HPRD	Entrez Gene	OMIM	HGNC
01821	7040	190180	HGNC:11766