Pancreatic Cancer Database

Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

Gene Symbol

MMP9

Chromosome Locus

20q11.2-q13.1

Alternate Names

Gelatinase B; Collagenase type IV B; CLG4B

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	DNA microarray	Increased	2	Segara et al. 2005
Invasive ductal adenocarcinoma	DNA microarray	Increased	5	Nakamura et al. 2004
Invasive ductal adenocarcinoma	DNA microarray	Increased	17.3	Friess et al. 2003
Invasive ductal adenocarcinoma	Northern blot	Increased		Kleeff et al. 1999
Invasive ductal adenocarcinoma	RT-PCR	Increased		Grutzmann et al. 2005
Invasive ductal adenocarcinoma	Northern blot	Increased		Wagner et al. 1999

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	DIGE, Tandem mass spectrometry	Increased	3.7	Tian et al.
Invasive ductal adenocarcinoma	Western blot	Increased		Tian et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Tian et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Tian et al.
Invasive ductal adenocarcinoma	ELISA	Increased		Tian et al.
Pancreatic cancer	Immunohistochemistry	Increased		Ohlund et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Qian et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Harvey et al.

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
PANC-1	SILAC, Tandem mass spectrometry	Decreased		Gronborg et al.

Chronic Pancreatitis

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

Secreted

Body Fluid

Serum

External Links

HPRD	Entrez Gene	OMIM	HGNC
00387	4318	120361	HGNC:7176