Pancreatic Cancer Database

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

Gene Symbol

SERPINA1

Chromosome Locus

14q32.1

Alternate Names

PI; PI1; AAT

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Endocrine Neoplasms	DNA microarray	Increased	12.5	Lowe et al. 2007
Endocrine Neoplasms	DNA microarray	Increased	19.3	Hansel et al. 2004
Intraductal papillary mucinous neoplasms	DNA microarray	Increased	37	Sato et al. 2004
Intraductal papillary mucinous neoplasms	RT-PCR	Increased		Sato et al. 2004
Intraductal papillary mucinous neoplasms	DNA microarray	Increased	72.5	Terris et al. 2002
Intraductal papillary mucinous neoplasms	DNA microarray	Increased	12.8	Sato et al. 2004
Invasive ductal adenocarcinoma	DNA microarray	Increased		Trachte et al. 2002

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	DIGE, Tandem mass spectrometry	Increased	3.4	Tian et al.
Pancreatic ductal adenocarcinoma	Western blot	Increased		Chung et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Trachte et al.
Invasive ductal adenocarcinoma	Label free quantitation, Mass spectrometry	Increased	4	Pan et al. 2011

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
RNA	DNA microarray	Increased	2	Binkley et al. 2004
RNA	DNA microarray	Increased	4.9	Rogers et al. 2006
RNA	RT-PCR	Increased		Rogers et al. 2006
Protein	Label free quantitation, Mass spectrometry	Increased	2.4	Pan et al. 2011

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

Secreted

Body Fluid

External Links

HPRD	Entrez Gene	OMIM	HGNC
02463	5265	107400	HGNC:8941