Pancreatic Cancer Database

Fibronectin 1

Gene Symbol

FN1

Chromosome Locus

2q34

Alternate Names

FN; LETS; Cold insoluble globulin

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Endocrine Neoplasms	DNA microarray	Increased	3	Maitra et al.
Intraductal papillary mucinous neoplasms	DNA microarray	Increased	6.8	Terris et al. 2002
Invasive ductal adenocarcinoma	DNA microarray	Increased	3.1	Cao et al. 2004
Invasive ductal adenocarcinoma	DNA microarray	Increased	6.5	Iacobuzio-Donahue et al. 2002
Invasive ductal adenocarcinoma	DNA microarray	Increased	5.5	Johnson et al. 2006
Invasive ductal adenocarcinoma	RT-PCR	Increased		Gress et al. 1997
Invasive ductal adenocarcinoma	DNA microarray	Increased	2.3	Buchholz et al. 2005
Invasive ductal adenocarcinoma	DNA microarray	Increased	6	Crnogorac-Jurcevic et al. 2003
Invasive ductal adenocarcinoma	DNA microarray	Increased	8	Tan et al. 2003
Invasive ductal adenocarcinoma	Northern blot	Increased		Gress et al. 1997
Invasive ductal adenocarcinoma	DNA microarray	Increased	9	Iacobuzio-Donahue et al. 2003
Invasive ductal adenocarcinoma	RT-PCR	Increased		Binkley et al. 2004
Invasive ductal adenocarcinoma	DNA microarray	Increased	5	Nakamura et al. 2004
Invasive ductal adenocarcinoma	DNA microarray	Increased		Binkley et al. 2004
Invasive ductal adenocarcinoma	DNA microarray	Increased	4.6	Lowe et al. 2007
Invasive ductal adenocarcinoma	DNA microarray	Increased	18.3	Jin et al. 2006
Invasive ductal adenocarcinoma	DNA microarray	Increased	17.8	Friess et al. 2003
Invasive ductal adenocarcinoma	SAGE	Increased		Terris et al. 2002
Invasive ductal adenocarcinoma	DNA microarray	Increased	2	Binkley et al. 2004
Congenital Cyst	DNA microarray	Increased	2	Binkley et al. 2004

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Wagner et al.
Invasive ductal adenocarcinoma	ICAT	Increased	2.4	Chen et al.
Endocrine Neoplasms	Immunohistochemistry	Increased		Maitra et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Loos et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Iacobuzio-Donahue et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Binkley et al.
Invasive ductal adenocarcinoma	Label free quantitation, Mass spectrometry	Increased	5.8	Pan et al. 2011
Pancreatic cancer	Mass spectrometry	Decreased	3.3	Kahlert et al. 2011

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
PANC-1	SILAC, Tandem mass spectrometry	Decreased		Gronborg et al.

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
RNA	DNA microarray	Increased	9.8	Friess et al.
Protein	Immunohistochemistry	Increased		Binkley et al.
Protein	Label free quantitation, Mass spectrometry	Increased	2.2	Pan et al. 2011
Protein	Label free quantitation, Mass spectrometry	Increased	5.1	Pan et al. 2011

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

Secreted

Body Fluid

External Links

HPRD	Entrez Gene	OMIM	HGNC
00626	2335	135600	HGNC:3778

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."