Pancreatic Cancer Database

Keratin 18

Gene Symbol

KRT18

Chromosome Locus

12q13

Alternate Names

K18; Cytokeratin 18; CYK18

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	SAGE	Increased		Miller et al. 2002
Invasive ductal adenocarcinoma	SAGE	Increased		Hustinx et al. 2004

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
CFPAC-1	RT-PCR	Increased		Nakatsura et al. 2001
Capan-2	RT-PCR	Increased		Nakatsura et al. 2001
HPAF-II	RT-PCR	Increased		Nakatsura et al. 2001
BxPC-3	RT-PCR	Increased		Nakatsura et al. 2001
PaCa-2	RT-PCR	Increased		Nakatsura et al. 2001
Panc-1	RT-PCR	Increased		Nakatsura et al. 2001
IMIM-PC-l	Northern blot	Increased		Paciucci et al. 1996
IMIM-PC-2	Northern blot	Increased		Paciucci et al. 1996
SK-PC-l	Northern blot	Increased		Paciucci et al. 1996
SK-PC-3	Northern blot	Increased		Paciucci et al. 1996

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	SILAC, Tandem mass spectrometry	Decreased	1.8	Yu et al.
Miscellaneous	Immunohistochemistry	Increased		Luttges et al.
Invasive ductal adenocarcinoma	Label free quantitation, Mass spectrometry	Decreased	2.1	Pan et al. 2011

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
BxPC-3	Immunohistochemistry	Increased		Rafiee et al. 1992
MIA PaCa-2	Immunohistochemistry	Increased		Rafiee et al. 1992
Panc-1	Immunohistochemistry	Increased		Rafiee et al. 1992
AsPC-1	Immunohistochemistry	Increased		Rafiee et al. 1992
SW1990	Immunohistochemistry	Increased		Rafiee et al. 1992
BxPC-3	Western blot	Increased		Rafiee et al. 1992
MIA PaCa-2	Western blot	Increased		Rafiee et al. 1992
Panc-1	Western blot	Increased		Rafiee et al. 1992
CAPAN-2	Western blot	Increased		Rafiee et al. 1992
AsPC-1	Western blot	Increased		Rafiee et al. 1992
SW1990	Western blot	Increased		Rafiee et al. 1992

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

-

Secreted

-

Body Fluid

Serum

External Links

HPRD	Entrez Gene	OMIM	HGNC
01020	3875	148070	HGNC:6430

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."