Pancreatic Cancer Database

Matrix metallopeptidase 7

Gene Symbol

MMP7

Chromosome Locus

11q21-q22

Alternate Names

Matrilysin, Uterine; Putative metalloproteinase I; PUMP1

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	SAGE	Increased		Hustinx et al. 2004
Invasive ductal adenocarcinoma	DNA microarray	Increased		Crnogorac-Jurcevic et al. 2002
Invasive ductal adenocarcinoma	DNA microarray	Increased	3	Iacobuzio-Donahue et al. 2003
Invasive ductal adenocarcinoma	Northern blot	Increased		Bramhall et al. 1997
Invasive ductal adenocarcinoma	In situ hybridization	Increased		Bramhall et al. 1997
Invasive ductal adenocarcinoma	DNA microarray	Increased	8.8	Iacobuzio-Donahue et al. 2002
Invasive ductal adenocarcinoma	DNA microarray	Increased	5.7	Laurell et al. 2006
PanIN-3	DNA microarray	Increased	2.9	Buchholz et al. 2005

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Pancreatic cancer	Immunohistochemistry	Increased		Ohlund et al.
Invasive ductal adenocarcinoma	SILAC, Tandem mass spectrometry	Decreased	1.6	Yu et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Grutzmann et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Li et al.
PanIN-2	Immunohistochemistry	Increased		Li et al.
Intraductal papillary mucinous neoplasm with moderate dysplasia	Immunohistochemistry	Increased		Nishikawa et al.
Intraductal papillary mucinous neoplasm with an associated invasive carcinoma	Immunohistochemistry	Increased		Nishikawa et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Nishikawa et al.

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

Secreted

Body Fluid

External Links

HPRD	Entrez Gene	OMIM	HGNC
01525	4316	178990	HGNC:7174