Pancreatic Cancer Database

Hypoxia inducible factor 1, alpha subunit

Gene Symbol

HIF1A

Chromosome Locus

14q21-q24

Alternate Names

Member of PAS superfamily 1; MOP1; ARNT interacting protein

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	DNA microarray	Increased	2.9	Laurell et al. 2006
Invasive ductal adenocarcinoma	DNA microarray	Increased	5.7	Iacobuzio-Donahue et al. 2002
Invasive ductal adenocarcinoma	Northern blot	Increased	13.1	Buchler et al. 2002
Invasive ductal adenocarcinoma	In situ hybridization	Increased		Buchler et al. 2002
Invasive ductal adenocarcinoma	RT-PCR	Increased		Wei et al. 2006
Invasive ductal adenocarcinoma	DNA microarray	Increased	2.8	Jin et al. 2006

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Pancreatic carcinoma	Immunohistochemistry	Increased		Miyake et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Sun et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Buchler et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Kitada et al.
Mucinous cystic neoplasms	Immunohistochemistry	Increased		Kitada et al.
Intraductal papillary mucinous neoplasms	Immunohistochemistry	Increased		Kitada et al.
Acinar cell carcinoma	Immunohistochemistry	Increased		Kitada et al.
Invasive ductal adenocarcinoma	Western blot	Increased		Crnogorac-Jurcevic et al.

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
RNA	DNA microarray	Increased	2	Binkley et al. 2004

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

Secreted

Body Fluid

External Links

HPRD	Entrez Gene	OMIM	HGNC
04517	3091	603348	HGNC:4910