Pancreatic Cancer Database

Interleukin 8

Gene Symbol

IL8

Chromosome Locus

4q13-q21

Alternate Names

IL-8; Small inducible cytokine subfamily B, member 8; SCYB8

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	qRT-PCR	Increased	38.5	Hussain et al.
Invasive ductal adenocarcinoma	RT-PCR	Increased		Li et al.
Invasive ductal adenocarcinoma	RT-PCR	Increased		Bellone et al. 2005
Invasive ductal adenocarcinoma	DNA microarray	Increased	12.5	Segara et al. 2005
Invasive ductal adenocarcinoma	DNA microarray	Increased	3	Iacobuzio-Donahue et al. 2003
Invasive ductal adenocarcinoma	DNA microarray	Increased	6.5	Iacobuzio-Donahue et al. 2002

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
MIA PaCa-2	RT-PCR	Increased		Li et al.
BxPC-3	RT-PCR	Increased		Li et al.
Capan-2	RT-PCR	Increased		Li et al.
HPAF-II	RT-PCR	Increased		Li et al.
Panc03.27	RT-PCR	Increased		Li et al.
AsPc1	DNA microarray	Increased	6.5	Iacobuzio-Donahue et al. 2002
BxPc3	DNA microarray	Increased	6.5	Iacobuzio-Donahue et al. 2002
CAPAN1	DNA microarray	Increased	6.5	Iacobuzio-Donahue et al. 2002
CAPAN2	DNA microarray	Increased	6.5	Iacobuzio-Donahue et al. 2002
CFPAC1	DNA microarray	Increased	6.5	Iacobuzio-Donahue et al. 2002
COLO357	DNA microarray	Increased	6.5	Iacobuzio-Donahue et al. 2002
Hs766T	DNA microarray	Increased	6.5	Iacobuzio-Donahue et al. 2002
MiaPaCa2	DNA microarray	Increased	6.5	Iacobuzio-Donahue et al. 2002
Panc-1	DNA microarray	Increased	6.5	Iacobuzio-Donahue et al. 2002
Su86.86	DNA microarray	Increased	6.5	Iacobuzio-Donahue et al. 2002
PT-45	RT-PCR	Increased		Bellone et al. 2005
Capan-2	RT-PCR	Increased		Bellone et al. 2005

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Hussain et al.
Invasive ductal adenocarcinoma	ELISA	Increased		Tjomsland et al.
Invasive ductal adenocarcinoma	ELISA	Increased		Bellone et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Bellone et al.
Pancreatic ductal adenocarcinoma	Antibody microarray	Increased		Kelber et al. 2012
Pancreatic ductal adenocarcinoma	Immunohistochemistry	Increased		Chen et al. 2012

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
BxPC-3	ELISA	Increased		Matsuo et al.
SW 1990	ELISA	Increased		Matsuo et al.
MIA PaCa-2	Bio-plex cytokine assay	Increased		Li et al.
BxPC-3	Bio-plex cytokine assay	Increased		Li et al.
PT-45	ELISA	Increased		Bellone et al. 2005
Capan-2	ELISA	Increased		Bellone et al. 2005
BxPC-3	ELISA	Increased		Bellone et al. 2005
PANC-1	ELISA	Increased		Bellone et al. 2005
MIAPaCa-2	ELISA	Increased		Bellone et al. 2005

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
Protein	ELISA	Increased		Tjomsland et al.
RNA	In situ hybridization	Increased		Saurer et al.
RNA	DNA microarray	Increased	9.3	Farrow et al.
RNA	Northern blot	Increased	41	Di et al.
Protein	Immunohistochemistry	Increased		Di et al.
Protein	Other assays	Increased		Zeh et al.
RNA	DNA microarray	Increased	8.7	Rogers et al. 2006

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

-

Secreted

19035451

Body Fluid

-

External Links

HPRD	Entrez Gene	OMIM	HGNC
00909	3576	146930	HGNC:6025

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."