Pancreatic Cancer Database

Mesothelin

Gene Symbol

MSLN

Chromosome Locus

16p13.3

Alternate Names

MPF; SMR; CAK1

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	DNA microarray	Decreased	5	Nakamura et al.
Intraductal papillary mucinous neoplasms	DNA microarray	Increased	83	Sato et al. 2004
Intraductal papillary mucinous neoplasms	RT-PCR	Increased		Sato et al. 2004
Invasive ductal adenocarcinoma	DNA microarray	Increased	8.5	Lowe et al. 2007
Invasive ductal adenocarcinoma	SAGE	Increased		Ryu et al. 2002
Invasive ductal adenocarcinoma	DNA microarray	Increased	3	Iacobuzio-Donahue et al. 2003
Invasive ductal adenocarcinoma	SAGE	Increased		Hustinx et al. 2004
Invasive ductal adenocarcinoma	DNA microarray	Increased	7	Logsdon et al. 2003
Invasive ductal adenocarcinoma	In situ hybridization	Increased		Argani et al. 2001
Invasive ductal adenocarcinoma	SAGE	Increased		Argani et al. 2001
Invasive ductal adenocarcinoma	RT-PCR	Increased		Watanabe et al. 2005
Intraductal papillary mucinous neoplasms	RT-PCR	Increased		Watanabe et al. 2005

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
Panc1	SAGE	Increased		Argani et al. 2001
CAPAN1	SAGE	Increased		Argani et al. 2001
CAPAN2	SAGE	Increased		Argani et al. 2001
PL-45	SAGE	Increased		Argani et al. 2001
AsPc-1	SAGE	Increased		Argani et al. 2001
AsPC1	RT-PCR	Increased		Argani et al. 2001
BxPC3	RT-PCR	Increased		Argani et al. 2001
CAPAN1	RT-PCR	Increased		Argani et al. 2001
CAPAN2	RT-PCR	Increased		Argani et al. 2001
CfPAC1	RT-PCR	Increased		Argani et al. 2001
PL-2	RT-PCR	Increased		Argani et al. 2001
PL-4	RT-PCR	Increased		Argani et al. 2001
PL-6	RT-PCR	Increased		Argani et al. 2001
PL-8	RT-PCR	Increased		Argani et al. 2001
PL-10	RT-PCR	Increased		Argani et al. 2001
PL-11	RT-PCR	Increased		Argani et al. 2001
PL-12	RT-PCR	Increased		Argani et al. 2001
PL-14	RT-PCR	Increased		Argani et al. 2001
AsPc1	SAGE	Increased		Ryu et al. 2002
CAPAN1	SAGE	Increased		Ryu et al. 2002
CAPAN2	SAGE	Increased		Ryu et al. 2002
Panc-1	SAGE	Increased		Ryu et al. 2002
PL45	SAGE	Increased		Ryu et al. 2002
BxPC-3	DNA microarray	Increased	7	Logsdon et al. 2003
MIA PaCa-2	DNA microarray	Increased	7	Logsdon et al. 2003
CFPAC-1	DNA microarray	Increased	7	Logsdon et al. 2003
HPAC	DNA microarray	Increased	7	Logsdon et al. 2003
MPanc-96	DNA microarray	Increased	7	Logsdon et al. 2003
SU.86.86	DNA microarray	Increased	7	Logsdon et al. 2003
SW1990	DNA microarray	Increased	7	Logsdon et al. 2003
AsPC1	SAGE	Increased		Hustinx et al. 2004
PL11	SAGE	Increased		Hustinx et al. 2004
MiaPaCa2	SAGE	Increased		Hustinx et al. 2004
BXPC3	SAGE	Increased		Hustinx et al. 2004
CFPAC1	SAGE	Increased		Hustinx et al. 2004
PL13	SAGE	Increased		Hustinx et al. 2004
PL3	SAGE	Increased		Hustinx et al. 2004
CAPAN2	SAGE	Increased		Hustinx et al. 2004
PL6	SAGE	Increased		Hustinx et al. 2004
PL4	SAGE	Increased		Hustinx et al. 2004
Hs766T	SAGE	Increased		Hustinx et al. 2004
Panc1	SAGE	Increased		Hustinx et al. 2004
PL12	SAGE	Increased		Hustinx et al. 2004
Su8696	SAGE	Increased		Hustinx et al. 2004

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Showalter et al.
Intraductal papillary mucinous neoplasms	Immunohistochemistry	Increased		Sato et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Ordonez et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Argani et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Hassan et al.
PanIN-1A	Immunohistochemistry	Increased		Hassan et al.
PanIN-1B	Immunohistochemistry	Increased		Hassan et al.
PanIN-2	Immunohistochemistry	Increased		Hassan et al.
PanIN-1A	Immunohistochemistry	Increased		Maitra et al.
PanIN-1B	Immunohistochemistry	Increased		Maitra et al.
PanIN-2	Immunohistochemistry	Increased		Maitra et al.
PanIN-3	Immunohistochemistry	Increased		Maitra et al.

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

Secreted

Body Fluid

External Links

HPRD	Entrez Gene	OMIM	HGNC
03030	10232	601051	HGNC:7371

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."