Pancreatic Cancer Database

Receptor tyrosine-protein kinase erbB-2

Gene Symbol

ERBB2

Chromosome Locus

17q11.2-q12;17q21.1

Alternate Names

ErbB2; NGL; NEU

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Pancreatic ductal adenocarcinoma	RT-PCR	Increased	4.1	Xue et al.
Invasive ductal adenocarcinoma	DNA microarray	Increased	5.7	Johnson et al. 2006
Invasive ductal adenocarcinoma	Northern blot	Increased	4	Yamanaka et al. 1993
Invasive ductal adenocarcinoma	In situ hybridization	Increased		Yamanaka et al. 1993
Invasive ductal adenocarcinoma	RT-PCR	Increased		Kolb et al. 2006
Invasive ductal adenocarcinoma	In situ hybridization	Increased		Saxby et al. 2005
Invasive ductal adenocarcinoma	RT-PCR	Increased	10	Saxby et al. 2005

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Komoto et al.
Endocrine Neoplasms	Immunohistochemistry	Increased		Wang et al.
Intraductal papillary mucinous neoplasm with low-grade dysplasia	Immunohistochemistry	Increased		Moriya et al.
Intraductal papillary mucinous neoplasm with high-grade dysplasia (carcinoma in situ)	Immunohistochemistry	Increased		Moriya et al.
PanIN-1A	Immunohistochemistry	Increased		Moriya et al.
PanIN-1B	Immunohistochemistry	Increased		Moriya et al.
PanIN-2	Immunohistochemistry	Increased		Moriya et al.
PanIN-3	Immunohistochemistry	Increased		Moriya et al.
Invasive	Immunohistochemistry	Increased		Moriya et al.
Intraductal papillary mucinous neoplasms	Immunohistochemistry	Increased		Satoh et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Saitou et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Zhang et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Schlieman et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Ueda et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Saxby et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Yamanaka et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Okada et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Gansauge et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Zhao et al.
Mucinous cystic neoplasms	Immunohistochemistry	Increased		Zhao et al.

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
MIA-PaCa-2	Western blot	Increased		Schlieman et al. 2003
AsPC-1	Western blot	Increased		Schlieman et al. 2003
BxPC-3	Western blot	Increased		Schlieman et al. 2003
L3.3	Western blot	Increased		Schlieman et al. 2003
CAPAN-1	Western blot	Increased		Schlieman et al. 2003
HPAF-II	Western blot	Increased		Schlieman et al. 2003

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
Protein	Immunohistochemistry	Increased		Gansauge et al.

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

Secreted

Body Fluid

External Links

HPRD	Entrez Gene	OMIM	HGNC
01281	2064	164870	HGNC:3430

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."