Pancreatic Cancer Database

Plasminogen activator, urokinase receptor

Gene Symbol

PLAUR

Chromosome Locus

19q13

Alternate Names

Plasminogen activator, urokinase receptor isoform 1 precursor; Plasminogen activator, urokinase receptor isoform 2 precursor; Plasminogen activator, urokinase receptor isoform 3 precursor

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Pancreatic ductal adenocarcinoma	RT-PCR	Increased	9.6	Xue et al.
Invasive ductal adenocarcinoma	In situ hybridization	Increased		Hildenbrand et al.
Invasive ductal adenocarcinoma	In situ hybridization	Increased		Hildenbrand et al.
PanIN-1, PanIN-2, PanIN-3	In situ hybridization	Increased		Hildenbrand et al.
Invasive ductal adenocarcinoma	DNA microarray	Increased	6.1	Jin et al. 2006
Invasive ductal adenocarcinoma	DNA microarray	Increased	13.5	Segara et al. 2005
Invasive ductal adenocarcinoma	DNA microarray	Increased	6.2	Iacobuzio-Donahue et al. 2002
Invasive ductal adenocarcinoma	DNA microarray	Increased	3	Iacobuzio-Donahue et al. 2003
Invasive ductal adenocarcinoma	DNA microarray	Increased	3.2	Lowe et al. 2007
Invasive ductal adenocarcinoma	DNA microarray	Increased	4.4	Iacobuzio-Donahue et al. 2003
Invasive ductal adenocarcinoma	DNA microarray	Increased	11	Logsdon et al. 2003

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
AsPc1	DNA microarray	Increased	6.2	Iacobuzio-Donahue et al. 2002
BxPc3	DNA microarray	Increased	6.2	Iacobuzio-Donahue et al. 2002
CAPAN1	DNA microarray	Increased	6.2	Iacobuzio-Donahue et al. 2002
CAPAN2	DNA microarray	Increased	6.2	Iacobuzio-Donahue et al. 2002
CFPAC1	DNA microarray	Increased	6.2	Iacobuzio-Donahue et al. 2002
COLO357	DNA microarray	Increased	6.2	Iacobuzio-Donahue et al. 2002
Hs766T	DNA microarray	Increased	6.2	Iacobuzio-Donahue et al. 2002
MiaPaCa2	DNA microarray	Increased	6.2	Iacobuzio-Donahue et al. 2002
Panc-1	DNA microarray	Increased	6.2	Iacobuzio-Donahue et al. 2002
Su86.86	DNA microarray	Increased	6.2	Iacobuzio-Donahue et al. 2002
BxPC-3	DNA microarray	Increased	5	Logsdon et al. 2003
MIA PaCa-2	DNA microarray	Increased	5	Logsdon et al. 2003
CFPAC-1	DNA microarray	Increased	5	Logsdon et al. 2003
HPAC	DNA microarray	Increased	5	Logsdon et al. 2003
MPanc-96	DNA microarray	Increased	5	Logsdon et al. 2003
SU.86.86	DNA microarray	Increased	5	Logsdon et al. 2003
SW1990	DNA microarray	Increased	5	Logsdon et al. 2003

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Hildenbrand et al.
PanIN-1, PanIN-2, PanIN-3	Immunohistochemistry	Increased		Hildenbrand et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Sawai et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Paciucci et al.

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
IMIM-PC-2	Western blot	Increased		Paciucci et al. 1998
IMIM-PC-1	Western blot	Increased		Paciucci et al. 1998
AsPC-1	Western blot	Increased		Paciucci et al. 1998
BxPC-3	Western blot	Increased		Sawai et al. 2006
Capan-2	Western blot	Increased		Sawai et al. 2006
SW1990	Western blot	Increased		Sawai et al. 2006

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
Protein	Immunohistochemistry	Increased		Paciucci et al.

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

Secreted

Body Fluid

External Links

HPRD	Entrez Gene	OMIM	HGNC
01421	5329	173391	HGNC:9053

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."