Pancreatic Cancer Database

Cathepsin D

Gene Symbol

CTSD

Chromosome Locus

11p15.5

Alternate Names

CATD; Cathepsin D, lysosomal aspartyl protease

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	DNA microarray	Increased	5.4	Iacobuzio-Donahue et al. 2003
Invasive ductal adenocarcinoma	DNA microarray	Increased	2.9	Laurell et al. 2006

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
AsPc1	DNA microarray	Increased	5.7	Iacobuzio-Donahue et al. 2003
BxPc3	DNA microarray	Increased	5.7	Iacobuzio-Donahue et al. 2003
CAPAN1	DNA microarray	Increased	5.7	Iacobuzio-Donahue et al. 2003
CAPAN2	DNA microarray	Increased	5.7	Iacobuzio-Donahue et al. 2003
CFPAC1	DNA microarray	Increased	5.7	Iacobuzio-Donahue et al. 2003
Hs766T	DNA microarray	Increased	5.7	Iacobuzio-Donahue et al. 2003
MiaPaca2	DNA microarray	Increased	5.7	Iacobuzio-Donahue et al. 2003
Panc-1	DNA microarray	Increased	5.7	Iacobuzio-Donahue et al. 2003
Su86.86	DNA microarray	Increased	5.7	Iacobuzio-Donahue et al. 2003

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	SILAC, Tandem mass spectrometry	Increased	2.4	Yu et al.
Invasive ductal adenocarcinoma	ICAT	Increased	3.4	Chen et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Chen et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Shen et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Chen et al.
Invasive ductal adenocarcinoma	Mass spectrometry	Increased	18.9	Shen et al.
Invasive ductal adenocarcinoma	Two dimensional electrophoresis	Increased	18.9	Shen et al.
Invasive ductal adenocarcinoma	Western blot	Increased	3.4	Chen et al.
Invasive ductal adenocarcinoma	Western blot	Increased	18.9	Shen et al.

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
Aspc-1	Western blot	Increased		Shen et al. 2004
Capan-1	Western blot	Increased		Shen et al. 2004
Capan-2	Western blot	Increased		Shen et al. 2004
Hs766T	Western blot	Increased		Shen et al. 2004
MiaPaCa-2	Western blot	Increased		Shen et al. 2004
Panc-1	Western blot	Increased		Shen et al. 2004
Panc-3	Western blot	Increased		Shen et al. 2004
Panc-48	Western blot	Increased		Shen et al. 2004
Panc-28	Western blot	Increased		Shen et al. 2004
Su-8666	Western blot	Increased		Shen et al. 2004
HPAF-11	Western blot	Increased		Shen et al. 2004
BxPC3	Western blot	Increased		Shen et al. 2004
	Western blot	Increased		Shen et al. 2004

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
Protein	ICAT	Increased	1.8	Chen et al.
Protein	Immunohistochemistry	Increased		Chen et al.
Protein	Immunohistochemistry	Increased		Chen et al.

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

-

Secreted

-

Body Fluid

Serum

External Links

HPRD	Entrez Gene	OMIM	HGNC
00291	1509	116840	HGNC:2529

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."