Secreted protein, acidic, cysteine-rich (osteonectin)
Gene Symbol   SPARC Chromosome Locus   5q31.3-q32
 
  Alternate Names    
     
 
Secreted protein acidic cysteine rich; Secreted protein acidic and rich in cysteine; Basement membrane protein BM-40
 
   
 
  RNA Alterations     
     
 
Cancer Type
Experiment Type
Expression Level
Fold Change
PubMed ID
Endocrine Neoplasms DNA microarray
Increased
3.2
Maitra et al. 2003
Invasive ductal adenocarcinoma RT-PCR
Increased
31
Guweidhi et al. 2005
Invasive ductal adenocarcinoma DNA microarray
Increased
5
Nakamura et al. 2004
Invasive ductal adenocarcinoma DNA microarray
Increased
3.2
Lowe et al. 2007
Invasive ductal adenocarcinoma DNA microarray
Increased
17.6
Friess et al. 2003
Invasive ductal adenocarcinoma DNA microarray
Increased
20.2
Tan et al. 2003
Cell Line
Experiment Type
Expression Level
Fold Change
PubMed ID
No Data
 
   
 
  Protein Alterations     
     
 
Cancer Type
Experiment Type
Expression Level
Fold Change
PubMed ID
Invasive ductal adenocarcinoma SILAC, Tandem mass spectrometry
Increased
56.7
 Yu et al.
Invasive ductal adenocarcinoma ELISA
Increased
Guweidhi et al.
Invasive ductal adenocarcinoma Immunohistochemistry
Increased
Guweidhi et al.
Pancreatic cancer Mass spectrometry
Increased
2.5
 Gebauer et al. 2011
Cell Line
Experiment Type
Expression Level
Fold Change
PubMed ID
PANC-1 SILAC, Tandem mass spectrometry
Decreased
Gronborg et al.
 
   
 
 Chronic Pancreatitis    
     
 
RNA/Protein
Experiment Type
Expression Level
Fold Change
PubMed ID
RNA DNA microarray
Increased
16.3
 Friess et al.
RNA RT-PCR
Increased
16
 Guweidhi et al.
Protein Immunocytochemistry
Increased
Guweidhi et al.
Protein Immunohistochemistry
Increased
Guweidhi et al.
Protein ELISA
Increased
Guweidhi et al.
RNA DNA microarray
Increased
2
 Binkley et al. 2004
 
   
 
 
  Expressed in Body Fluid /Plasma Membrane  
     
 
     
 
Plasma Membrane -
Secreted - 
Body Fluid
Plasma Pan et al.
Serum Yu et al.
 
   
 
   
 
  External Links     
     
 
HPRD
Entrez Gene
OMIM
HGNC
 
   
 
 
 
 

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."