Pancreatic Cancer Database

SMAD family member 4

Gene Symbol

SMAD4

Chromosome Locus

18q21.1

Alternate Names

SMA and MAD related protein 4; Deletion target in pancreatic carcinoma 4; DPC4

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Adenosquamous carcinoma	Immunohistochemistry	Increased		Brody et al.
Adenosquamous carcinoma of the pancreas	Immunohistochemistry	Decreased		Brody et al.
Intraductal papillary mucinous neoplasm with an associated invasive carcinoma	Immunohistochemistry	Increased		Takahashi et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Takahashi et al.
Intraductal papillary mucinous neoplasm with high-grade dysplasia (carcinoma in situ)	Immunohistochemistry	Increased		Moriya et al.
PanIN-3	Immunohistochemistry	Increased		Moriya et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Moriya et al.
Intraductal papillary mucinous neoplasms	Immunohistochemistry	Increased		Luttges et al.
Intraductal papillary mucinous neoplasm with an associated invasive carcinoma	Immunohistochemistry	Increased		Luttges et al.
Intraductal oncocytic papillary neoplasm	Immunohistochemistry	Increased		Luttges et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Luttges et al.
Coll	Immunohistochemistry	Increased		Luttges et al.
Intraductal papillary mucinous neoplasms	Immunohistochemistry	Increased		Luttges et al.
Intraductal papillary mucinous neoplasm with an associated invasive carcinoma	Immunohistochemistry	Increased		Luttges et al.
Intraductal oncocytic papillary neoplasm	Immunohistochemistry	Increased		Luttges et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Luttges et al.
Coll	Immunohistochemistry	Increased		Luttges et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Tascilar et al.
Mucinous cystic neoplasm with low-grade dysplasia	Immunohistochemistry	Increased		Iacobuzio-Donahue et al.
Mucinous cystic neoplasm with moderate dysplasia	Immunohistochemistry	Increased		Iacobuzio-Donahue et al.
Mucinous cystic neoplasm with high-grade dysplasia (carcinoma in situ)	Immunohistochemistry	Increased		Iacobuzio-Donahue et al.
PanIN-1A	Immunohistochemistry	Increased		Luttges et al.
PanIN-1B	Immunohistochemistry	Increased		Luttges et al.
PanIN-2	Immunohistochemistry	Increased		Luttges et al.
PanIN-3	Immunohistochemistry	Increased		Luttges et al.
PanIN-1A	Immunohistochemistry	Increased		Wilentz et al.
PanIN-1B	Immunohistochemistry	Increased		Wilentz et al.
PanIN-2	Immunohistochemistry	Increased		Wilentz et al.
PanIN-3	Immunohistochemistry	Increased		Wilentz et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Wilentz et al.
PanIN-3	Immunohistochemistry	Increased		Biankin et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Biankin et al.
Intraductal papillary mucinous neoplasm with low-grade dysplasia	Immunohistochemistry	Increased		Iacobuzio-Donahue et al.
Intraductal papillary mucinous neoplasm with moderate dysplasia	Immunohistochemistry	Increased		Iacobuzio-Donahue et al.
Intraductal papillary mucinous neoplasm with high-grade dysplasia (ca	Immunohistochemistry	Increased		Iacobuzio-Donahue et al.

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

Secreted

Body Fluid

External Links

HPRD	Entrez Gene	OMIM	HGNC
02995	4089	600993	HGNC:6770

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."