ADAM metallopeptidase domain 17
Gene Symbol   ADAM17 Chromosome Locus   2p25
 
  Alternate Names    
     
 
A disintegrin and metalloproteinase domain 17; Tumor necrosis factor alpha converting enzyme; TACE
 
   
 
  RNA Alterations     
     
 
Cancer Type
Experiment Type
Expression Level
Fold Change
PubMed ID
No Data
Cell Line
Experiment Type
Expression Level
Fold Change
PubMed ID
PDEC RT-PCR
Increased
Ringel et al. 2006
CAPAN-1 RT-PCR
Increased
Ringel et al. 2006
CAPAN-2 BxPC-3 RT-PCR
Increased
Ringel et al. 2006
PANC-1 RT-PCR
Increased
Ringel et al. 2006
HPAF/CD18 RT-PCR
Increased
Ringel et al. 2006
T3N4 RT-PCR
Increased
Ringel et al. 2006
QGP1 RT-PCR
Increased
Ringel et al. 2006
SW979 RT-PCR
Increased
Ringel et al. 2006
Colo357 RT-PCR
Increased
Ringel et al. 2006
 
   
 
  Protein Alterations     
     
 
Cancer Type
Experiment Type
Expression Level
Fold Change
PubMed ID
Invasive ductal adenocarcinoma Immunohistochemistry
Increased
Kahlert et al.
Invasive ductal adenocarcinoma Immunohistochemistry
Increased
Ringel et al.
PanIN-3 Immunohistochemistry
Increased
Ringel et al.
Cell Line
Experiment Type
Expression Level
Fold Change
PubMed ID
CAPAN-1 FACS
Increased
Ringel et al. 2006
PANC-1 FACS
Increased
Ringel et al. 2006
BxPC-3 FACS
Increased
Ringel et al. 2006
PDEC FACS
Increased
Ringel et al. 2006
CAPAN-1 Western blot
Increased
Ringel et al. 2006
CAPAN-2 Western blot
Increased
Ringel et al. 2006
BxPC-3 Western blot
Increased
Ringel et al. 2006
HPAF/CD18 Western blot
Increased
Ringel et al. 2006
PANC-1 Western blot
Increased
Ringel et al. 2006
T3N4 Western blot
Increased
Ringel et al. 2006
QGP1 Western blot
Increased
Ringel et al. 2006
SW979 Western blot
Increased
Ringel et al. 2006
 
   
 
 Chronic Pancreatitis    
     
 
RNA/Protein
Experiment Type
Expression Level
Fold Change
PubMed ID
RNA RT-PCR
Increased
Ringel et al. 2006
 
   
 
 
  Expressed in Body Fluid /Plasma Membrane  
     
 
     
 
Plasma Membrane -
Secreted
Body Fluid
-
 
   
 
   
 
  External Links     
     
 
HPRD
Entrez Gene
OMIM
HGNC
 
   
 
 
 
 

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."