Pancreatic Cancer Database

Vascular endothelial growth factor A

Gene Symbol

VEGFA

Chromosome Locus

6p12

Alternate Names

Vascular endothelial growth factor A; Vascular permeability factor

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Pancreatic ductal adenocarcinoma	RT-PCR	Increased		Liang et al.
Pancreatic carcinoma	RT-PCR	Increased	3.9	Zhu et al.
Invasive ductal adenocarcinoma	In situ hybridization	Increased		Itakura et al. 1997
Invasive ductal adenocarcinoma	Northern blot	Increased	5.2	Itakura et al. 1997
Invasive ductal adenocarcinoma	Northern blot	Increased	4.3	Itakura et al. 1999
Invasive ductal adenocarcinoma	In situ hybridization	Increased		von et al. 2000
Invasive ductal adenocarcinoma	RT-PCR	Increased		Arafat et al. 2007
Invasive ductal adenocarcinoma	RT-PCR	Increased	92	Fukahi et al. 2004
Invasive ductal adenocarcinoma	In situ hybridization	Increased		Buchler et al. 2002
Invasive ductal adenocarcinoma	Northern blot	Increased		Shi et al. 2001
Invasive ductal adenocarcinoma	DNA microarray	Increased		Trachte et al. 2002

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
AsPc-1	RT-PCR	Increased		von et al. 2000
Capan-1	RT-PCR	Increased		von et al. 2000
Capan-2	RT-PCR	Increased		von et al. 2000
Dan-G	RT-PCR	Increased		von et al. 2000
Panc-1	RT-PCR	Increased		von et al. 2000
AsPc-1	Northern blot	Increased		Shi et al. 2001
Bxpc-3	Northern blot	Increased		Shi et al. 2001
FG	Northern blot	Increased		Shi et al. 2001
PANC-1	Northern blot	Increased		Shi et al. 2001
SW-1990	Northern blot	Increased		Shi et al. 2001
CAPAN-1	RT-PCR	Increased		Fukahi et al. 2004
PK9	RT-PCR	Increased		Arafat et al. 2007
HS766T	RT-PCR	Increased		Arafat et al. 2007
CFPAC-1	RT-PCR	Increased		Fujimoto et al. 1998

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Pancreatic ductal adenocarcinoma	Immunohistochemistry	Increased		Liang et al.
Pancreatic ductal adenocarcinoma	Western blot	Increased		Liang et al.
Invasive ductal adenocarcinoma	ELISA	Increased	2	Pistol-Tanase et al.
Invasive ductal adenocarcinoma	Multiple proximity ligation assay	Increased	2.2	Hussain et al.
Pancreatic carcinoma	Western blot	Increased	7.2	Zhu et al.
Invasive ductal adenocarcinoma	ELISA	Increased		Kobayashi et al.
Intraductal papillary mucinous neoplasm with moderate dysplasia	Immunohistochemistry	Increased		Nishikawa et al.
Intraductal papillary mucinous neoplasm with an associated invasive carcinoma	Immunohistochemistry	Increased		Nishikawa et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Nishikawa et al.
Intraductal papillary mucinous neoplasms	Immunohistochemistry	Increased		Anandanadesan et al.
Pancreatic intraepithelial neoplasia	Immunohistochemistry	Increased		Anandanadesan et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Khorana et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Itakura et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		von et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Sun et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Shi et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Fujimoto et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Trachte et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Itakura et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Arafat et al.
Invasive ductal adenocarcinoma	Western blot	Increased		Arafat et al.
Pancreatic ductal adenocarcinoma	Antibody microarray	Increased		Kelber et al. 2012

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
AsPc-1	ELISA	Increased		Shi et al. 2001
Bxpc-3	ELISA	Increased		Shi et al. 2001
CaPan-1	ELISA	Increased		Shi et al. 2001
CaPan-2	ELISA	Increased		Shi et al. 2001
HPAFII	ELISA	Increased		Shi et al. 2001
HS766T	ELISA	Increased		Shi et al. 2001
MiaPaca-2	ELISA	Increased		Shi et al. 2001
PANC-1	ELISA	Increased		Shi et al. 2001
SW-1990	ELISA	Increased		Shi et al. 2001
MDA Panc-3	ELISA	Increased		Shi et al. 2001
MDA Panc-28	ELISA	Increased		Shi et al. 2001
MDA Panc-48	ELISA	Increased		Shi et al. 2001
COLO357	ELISA	Increased		Shi et al. 2001
AsPc-1	ELISA	Increased		von et al. 2000
Capan-1	ELISA	Increased		von et al. 2000
Panc-1	ELISA	Increased		von et al. 2000
Dan-G	ELISA	Increased		von et al. 2000
ASPC-I	Western blot	Increased		Itakura et al. 1997
CAPAN- 1	Western blot	Increased		Itakura et al. 1997
MIA-PaCa-2	Western blot	Increased		Itakura et al. 1997
PANC- I	Western blot	Increased		Itakura et al. 1997
T3M4	Western blot	Increased		Itakura et al. 1997
COLO-357	Western blot	Increased		Itakura et al. 1997
PANC-1	Western blot	Increased		Fujimoto et al. 1998
AsPC-1	Western blot	Increased		Fujimoto et al. 1998
MIAPaCa-2	Western blot	Increased		Fujimoto et al. 1998
CFPAC-1	Western blot	Increased		Fujimoto et al. 1998
Capan-2	Western blot	Increased		Fujimoto et al. 1998

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

Secreted

Body Fluid

External Links

HPRD	Entrez Gene	OMIM	HGNC
01889	7422	192240	HGNC:12680

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."