Pancreatic Cancer Database

Trefoil factor 2 (spasmolytic protein 1)

Gene Symbol

TFF2

Chromosome Locus

21q22.3

Alternate Names

Spasmolytic protein 1; Spasmolytic polypeptide; Spasmolysin

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Intraductal papillary mucinous neoplasms	DNA microarray	Increased	65.8	Terris et al. 2002
Invasive ductal adenocarcinoma	DNA microarray	Increased	3	Iacobuzio-Donahue et al. 2003
Invasive ductal adenocarcinoma	DNA microarray	Increased	8.7	Johnson et al. 2006
Invasive ductal adenocarcinoma	SAGE	Increased		Hustinx et al. 2004
Invasive ductal adenocarcinoma	SAGE	Increased		Terris et al. 2002
Invasive ductal adenocarcinoma	SAGE	Increased		Hustinx et al. 2004
PanIN-1A	RT-PCR	Increased		Buchholz et al. 2005
PanIN-1B	RT-PCR	Increased		Buchholz et al. 2005
PanIN-1A	DNA microarray	Increased	6.3	Buchholz et al. 2005
PanIN-1B	DNA microarray	Increased	6.3	Buchholz et al. 2005
PanIN-1A	DNA microarray	Increased	1.9	Prasad et al. 2005
PanIN-1B	DNA microarray	Increased	1.9	Prasad et al. 2005
PanIN-2	DNA microarray	Increased	1.9	Prasad et al. 2005

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
AsPC-1	RT-PCR	Increased		Argani et al. 2001
BxPC-3	RT-PCR	Increased		Argani et al. 2001
Capan-1	RT-PCR	Increased		Argani et al. 2001
CfPAC1	RT-PCR	Increased		Argani et al. 2001
PL1	RT-PCR	Increased		Argani et al. 2001
PL2	RT-PCR	Increased		Argani et al. 2001
PL3	RT-PCR	Increased		Argani et al. 2001
PL4	RT-PCR	Increased		Argani et al. 2001
PL5	RT-PCR	Increased		Argani et al. 2001
PL6	RT-PCR	Increased		Argani et al. 2001
PL8	RT-PCR	Increased		Argani et al. 2001
PL9	RT-PCR	Increased		Argani et al. 2001
PL10	RT-PCR	Increased		Argani et al. 2001
PL11	RT-PCR	Increased		Argani et al. 2001
PL13	RT-PCR	Increased		Argani et al. 2001
PL14	RT-PCR	Increased		Argani et al. 2001
AsPC1	SAGE	Increased		Hustinx et al. 2004
PL11	SAGE	Increased		Hustinx et al. 2004
MiaPaCa2	SAGE	Increased		Hustinx et al. 2004
BXPC3	SAGE	Increased		Hustinx et al. 2004
CFPAC1	SAGE	Increased		Hustinx et al. 2004
PL13	SAGE	Increased		Hustinx et al. 2004
PL3	SAGE	Increased		Hustinx et al. 2004
CAPAN2	SAGE	Increased		Hustinx et al. 2004
PL6	SAGE	Increased		Hustinx et al. 2004
PL4	SAGE	Increased		Hustinx et al. 2004
Hs766T	SAGE	Increased		Hustinx et al. 2004
Panc1	SAGE	Increased		Hustinx et al. 2004
PL12	SAGE	Increased		Hustinx et al. 2004
Su8722	SAGE	Increased		Hustinx et al. 2004
AsPC1	SAGE	Increased		Hustinx et al. 2004
PL11	SAGE	Increased		Hustinx et al. 2004
MiaPaCa2	SAGE	Increased		Hustinx et al. 2004
BXPC3	SAGE	Increased		Hustinx et al. 2004
CFPAC1	SAGE	Increased		Hustinx et al. 2004
PL13	SAGE	Increased		Hustinx et al. 2004
PL3	SAGE	Increased		Hustinx et al. 2004
CAPAN2	SAGE	Increased		Hustinx et al. 2004
PL6	SAGE	Increased		Hustinx et al. 2004
PL4	SAGE	Increased		Hustinx et al. 2004
Hs766T	SAGE	Increased		Hustinx et al. 2004
Panc1	SAGE	Increased		Hustinx et al. 2004
PL12	SAGE	Increased		Hustinx et al. 2004
Su8723	SAGE	Increased		Hustinx et al. 2004

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Terris et al.
Intraductal papillary mucinous neoplasms	Immunohistochemistry	Increased		Terris et al.

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

Secreted

Body Fluid

External Links

HPRD	Entrez Gene	OMIM	HGNC
01682	7032	182590	HGNC:11756

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."