Pancreatic Cancer Database

Topoisomerase (DNA) II alpha 170kDa

Gene Symbol

TOP2A

Chromosome Locus

17q21-q22

Alternate Names

DNA topoisomerase II; TOP2; EC 5.99.1.3

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Intraductal papillary mucinous neoplasms	DNA microarray	Increased	15	Sato et al. 2004
Invasive ductal adenocarcinoma	DNA microarray	Increased	13.2	Johnson et al. 2006
Invasive ductal adenocarcinoma	DNA microarray	Increased	3.3	Grutzmann et al. 2004
Invasive ductal adenocarcinoma	DNA microarray	Increased	3	Iacobuzio-Donahue et al. 2003
Invasive ductal adenocarcinoma	DNA microarray	Increased	5.3	Iacobuzio-Donahue et al. 2002

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Hansel et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Iacobuzio-Donahue et al.

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

Secreted

Body Fluid

External Links

HPRD	Entrez Gene	OMIM	HGNC
00536	7153	126430	HGNC:11989