Plasminogen activator, urokinase
Gene Symbol   PLAU Chromosome Locus   10q24
 
  Alternate Names    
     
 
Urokinase; URK; Plasminogen activator urinary
 
   
 
  RNA Alterations     
     
 
Cancer Type
Experiment Type
Expression Level
Fold Change
PubMed ID
Pancreatic ductal adenocarcinoma RT-PCR
Increased
7.6
Xue et al.
Invasive ductal adenocarcinoma DNA microarray
Increased
5
Nakamura et al. 2004
Invasive ductal adenocarcinoma In situ hybridization
Increased
Harvey et al. 2003
Invasive ductal adenocarcinoma RT-PCR
Increased
Nielsen et al. 2005
Invasive ductal adenocarcinoma DNA microarray
Increased
3
Iacobuzio-Donahue et al. 2003
Invasive ductal adenocarcinoma DNA microarray
Increased
5
Crnogorac-Jurcevic et al. 2003
Invasive ductal adenocarcinoma DNA microarray
Increased
3.2
Lowe et al. 2007
Invasive ductal adenocarcinoma DNA microarray
Increased
5.7
Iacobuzio-Donahue et al. 2002
Invasive ductal adenocarcinoma DNA microarray
Increased
2
Laurell et al. 2006
Cell Line
Experiment Type
Expression Level
Fold Change
PubMed ID
MiaPaCa-2 Northern blot
Increased
Wang et al. 1999
Hs-766T Northern blot
Increased
Wang et al. 1999
CFPAC-1 Northern blot
Increased
Wang et al. 1999
CAPAN-2 Northern blot
Increased
Wang et al. 1999
MDAPanc48 Northern blot
Increased
Wang et al. 1999
MDAPanc28 Northern blot
Increased
Wang et al. 1999
MDAPanc3 Northern blot
Increased
Wang et al. 1999
Panc-1 Northern blot
Increased
Wang et al. 1999
AsPc1 DNA microarray
Increased
5.7
 Iacobuzio-Donahue et al. 2002
BxPc3 DNA microarray
Increased
5.7
 Iacobuzio-Donahue et al. 2002
CAPAN1 DNA microarray
Increased
5.7
 Iacobuzio-Donahue et al. 2002
CAPAN2 DNA microarray
Increased
5.7
 Iacobuzio-Donahue et al. 2002
CFPAC1 DNA microarray
Increased
5.7
 Iacobuzio-Donahue et al. 2002
COLO357 DNA microarray
Increased
5.7
 Iacobuzio-Donahue et al. 2002
Hs766T DNA microarray
Increased
5.7
 Iacobuzio-Donahue et al. 2002
MiaPaCa2 DNA microarray
Increased
5.7
 Iacobuzio-Donahue et al. 2002
Panc-1 DNA microarray
Increased
5.7
 Iacobuzio-Donahue et al. 2002
Su86.86 DNA microarray
Increased
5.7
 Iacobuzio-Donahue et al. 2002
 
   
 
  Protein Alterations     
     
 
Cancer Type
Experiment Type
Expression Level
Fold Change
PubMed ID
Invasive ductal adenocarcinoma ELISA
Increased
Herszenyi et al.
Invasive ductal adenocarcinoma SILAC, Tandem mass spectrometry
Increased
2.6
 Yu et al.
Invasive ductal adenocarcinoma Immunohistochemistry
Increased
Wang et al.
Invasive ductal adenocarcinoma Immunohistochemistry
Increased
Nielsen et al.
Invasive ductal adenocarcinoma Immunohistochemistry
Increased
Paciucci et al.
Invasive ductal adenocarcinoma Immunohistochemistry
Increased
Harvey et al.
PanIN-1A Immunohistochemistry
Increased
Harvey et al.
PanIN-1B Immunohistochemistry
Increased
Harvey et al.
PanIN-2 Immunohistochemistry
Increased
Harvey et al.
PanIN-3 Immunohistochemistry
Increased
Harvey et al.
Cell Line
Experiment Type
Expression Level
Fold Change
PubMed ID
CFPAC-1 Western blot
Increased
Wang et al. 1999
 
   
 
 Chronic Pancreatitis    
     
 
RNA/Protein
Experiment Type
Expression Level
Fold Change
PubMed ID
Protein Immunohistochemistry
Increased
Paciucci et al.
 
   
 
 
  Expressed in Body Fluid /Plasma Membrane  
     
 
     
 
Plasma Membrane -
Secreted - 
Body Fluid
Plasma Herszenyi et al.
Serum Yu et al.
 
   
 
   
 
  External Links     
     
 
HPRD
Entrez Gene
OMIM
HGNC
 
   
 
 
 
 

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."