Pancreatic Cancer Database

Baculoviral IAP repeat-containing 5 (survivin)

Gene Symbol

BIRC5

Chromosome Locus

17q25

Alternate Names

Apoptosis inhibitor 4; Baculoviral IAP repeat containing protein 5; Apoptosis inhibitor survivin

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	RT-PCR	Increased	22	Bhanot et al. 2006
Invasive ductal adenocarcinoma	In situ hybridization	Increased		Lopes et al. 2007
Invasive ductal adenocarcinoma	RT-PCR	Increased		Satoh et al. 2001
Invasive ductal adenocarcinoma	RT-PCR	Increased		Nakamura et al. 2004
Invasive ductal adenocarcinoma	DNA microarray	Increased	5	Nakamura et al. 2004
Invasive ductal adenocarcinoma	RT-PCR	Increased		Lopes et al. 2007
Invasive ductal adenocarcinoma	RT-PCR	Increased		Bhanot et al. 2006
Invasive ductal adenocarcinoma	In situ hybridization	Increased		Lopes et al. 2007
Invasive ductal adenocarcinoma	RT-PCR	Increased		Lopes et al. 2007
PanIN-1A	RT-PCR	Increased	4.8	Bhanot et al. 2006
PanIN-1B	RT-PCR	Increased	4.8	Bhanot et al. 2006
PanIN-2	RT-PCR	Increased	10	Bhanot et al. 2006
PanIN-3	RT-PCR	Increased	14	Bhanot et al. 2006

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Intraductal papillary mucinous neoplasms	Immunohistochemistry	Increased		Satoh et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Satoh et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Lopes et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Sun et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Qiao et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Wei et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Lopes et al.
PanIN-1A	Immunohistochemistry	Increased		Bhanot et al.
PanIN-1B	Immunohistochemistry	Increased		Bhanot et al.
PanIN-2	Immunohistochemistry	Increased		Bhanot et al.
PanIN-3	Immunohistochemistry	Increased		Bhanot et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Bhanot et al.
Intraductal papillary mucinous neoplasms	Western blot	Increased		Satoh et al.
Invasive ductal adenocarcinoma	Western blot	Increased		Satoh et al.

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

Secreted

Body Fluid

External Links

HPRD	Entrez Gene	OMIM	HGNC
04520	332	603352	HGNC:593