Pancreatic Cancer Database

Prostate stem cell antigen

Gene Symbol

PSCA

Chromosome Locus

8q24.2

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Intraductal papillary mucinous neoplasms	RT-PCR	Increased		Sato et al. 2004
Intraductal papillary mucinous neoplasms	DNA microarray	Increased	44.2	Sato et al. 2004
Invasive ductal adenocarcinoma	SAGE	Increased		Hustinx et al. 2004
Invasive ductal adenocarcinoma	DNA microarray	Increased	7	Lowe et al. 2007
Invasive ductal adenocarcinoma	DNA microarray	Increased	5	Nakamura et al. 2004
Invasive ductal adenocarcinoma	SAGE	Increased		Miller et al. 2002
Invasive ductal adenocarcinoma	DNA microarray	Increased	5.3	Iacobuzio-Donahue et al. 2002
Invasive ductal adenocarcinoma	DNA microarray	Increased	3	Iacobuzio-Donahue et al. 2003
Invasive ductal adenocarcinoma	RT-PCR	Increased	179	Wente et al. 2005
Mucinous cystic neoplasms	RT-PCR	Increased	4	Fukushima et al. 2004
Mucinous cystic neoplasms	DNA microarray	Increased	7.7	Fukushima et al. 2004

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
AsPC-1	RT-PCR	Increased		Argani et al. 2001
BxPC-3	RT-PCR	Increased		Argani et al. 2001
Capan-1	RT-PCR	Increased		Argani et al. 2001
CfPAC1	RT-PCR	Increased		Argani et al. 2001
HPDE	RT-PCR	Increased		Argani et al. 2001
PL1	RT-PCR	Increased		Argani et al. 2001
PL2	RT-PCR	Increased		Argani et al. 2001
PL3	RT-PCR	Increased		Argani et al. 2001
PL4	RT-PCR	Increased		Argani et al. 2001
PL5	RT-PCR	Increased		Argani et al. 2001
PL6	RT-PCR	Increased		Argani et al. 2001
PL8	RT-PCR	Increased		Argani et al. 2001
PL9	RT-PCR	Increased		Argani et al. 2001
PL13	RT-PCR	Increased		Argani et al. 2001
PL14	RT-PCR	Increased		Argani et al. 2001
CAPAN1	SAGE	Increased		Argani et al. 2001
CAPAN2	SAGE	Increased		Argani et al. 2001
AsPC1	SAGE	Increased		Hustinx et al. 2004
PL11	SAGE	Increased		Hustinx et al. 2004
MiaPaCa2	SAGE	Increased		Hustinx et al. 2004
BXPC3	SAGE	Increased		Hustinx et al. 2004
CFPAC1	SAGE	Increased		Hustinx et al. 2004
PL13	SAGE	Increased		Hustinx et al. 2004
PL3	SAGE	Increased		Hustinx et al. 2004
CAPAN2	SAGE	Increased		Hustinx et al. 2004
PL6	SAGE	Increased		Hustinx et al. 2004
PL4	SAGE	Increased		Hustinx et al. 2004
Hs766T	SAGE	Increased		Hustinx et al. 2004
Panc1	SAGE	Increased		Hustinx et al. 2004
PL12	SAGE	Increased		Hustinx et al. 2004
Su8706	SAGE	Increased		Hustinx et al. 2004
Capan-1	RT-PCR	Increased		Wente et al. 2005
AsPC-1	RT-PCR	Increased		Wente et al. 2005
Capan-2	RT-PCR	Increased		Wente et al. 2005
ASPC	RT-PCR	Increased		Grubbs et al. 2006
COLO357	RT-PCR	Increased		Grubbs et al. 2006
PANC-1	RT-PCR	Increased		Grubbs et al. 2006
CFPAC	RT-PCR	Increased		Grubbs et al. 2006
HS766T	RT-PCR	Increased		Grubbs et al. 2006

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Intraductal papillary mucinous neoplasms	Immunohistochemistry	Increased		Sato et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Argani et al.
Pancreatic intraepithelial neoplasia	Immunohistochemistry	Increased		Argani et al.
Mucinous cystic neoplasms	Immunohistochemistry	Increased		Fukushima et al.
PanIN-1A	Immunohistochemistry	Increased		Fukushima et al.
PanIN-1B	Immunohistochemistry	Increased		Fukushima et al.
PanIN-2	Immunohistochemistry	Increased		Fukushima et al.
PanIN-3	Immunohistochemistry	Increased		Fukushima et al.

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
Capan-1	FACS	Increased		Wente et al. 2005

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

Secreted

Body Fluid

External Links

HPRD	Entrez Gene	OMIM	HGNC
03919	8000	602470	HGNC:9500

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."