Pancreatic Cancer Database

Antigen identified by monoclonal antibody Ki-67

Gene Symbol

MKI67

Chromosome Locus

10q25-qter

Alternate Names

Proliferation related Ki 67 antigen; KIA; Ki-67

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	DNA microarray	Increased	3	Iacobuzio-Donahue et al. 2003

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Endocrine Neoplasms	Immunohistochemistry	Increased		Yamamoto et al.
Intraductal papillary mucinous neoplasm with low-grade dysplasia	Immunohistochemistry	Increased		Moriya et al.
Intraductal papillary mucinous neoplasm with high-grade dysplasia (carcinoma in situ)	Immunohistochemistry	Increased		Moriya et al.
PanIN-1A	Immunohistochemistry	Increased		Moriya et al.
PanIN-1B	Immunohistochemistry	Increased		Moriya et al.
PanIN-2	Immunohistochemistry	Increased		Moriya et al.
PanIN-3	Immunohistochemistry	Increased		Moriya et al.
Invasive	Immunohistochemistry	Increased		Moriya et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Gansauge et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Zhao et al.
Mucinous cystic neoplasms	Immunohistochemistry	Increased		Zhao et al.
PanIN-2	Immunohistochemistry	Increased		Maitra et al.
PanIN-3	Immunohistochemistry	Increased		Maitra et al.
PanIN-2	Immunohistochemistry	Increased		Klein et al.
PanIN-3	Immunohistochemistry	Increased		Klein et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Klein et al.
Intraductal papillary mucinous neoplasm with low-grade dysplasia	Immunohistochemistry	Increased		Abe et al.
Intraductal papillary mucinous neoplasm with moderate dysplasia	Immunohistochemistry	Increased		Abe et al.
Intraductal papillary mucinous neoplasm with high-grade dysplasia (c	Immunohistochemistry	Increased		Abe et al.
Pancreatic cancer	Immunohistochemistry	Increased		Hu et al. 2012

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

Secreted

Body Fluid

External Links

HPRD	Entrez Gene	OMIM	HGNC
08902	4288	176741	HGNC:7107

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."