Pancreatic Cancer Database

Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)

Gene Symbol

TGM2

Chromosome Locus

20q12

Alternate Names

Transglutaminase tissue; Transglutaminase C; TGC

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	DNA microarray	Increased	2.9	Segara et al. 2005
Invasive ductal adenocarcinoma	SAGE	Increased		Ryu et al. 2002
Invasive ductal adenocarcinoma	DNA microarray	Increased	5.2	Iacobuzio-Donahue et al. 2002
Invasive ductal adenocarcinoma	DNA microarray	Increased	11.1	Iacobuzio-Donahue et al. 2003

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
AsPc1	SAGE	Increased		Ryu et al. 2002
CAPAN1	SAGE	Increased		Ryu et al. 2002
CAPAN2	SAGE	Increased		Ryu et al. 2002
Panc-1	SAGE	Increased		Ryu et al. 2002
PL45	SAGE	Increased		Ryu et al. 2002
AsPc1	DNA microarray	Increased	5.2	Iacobuzio-Donahue et al. 2002
BxPc3	DNA microarray	Increased	5.2	Iacobuzio-Donahue et al. 2002
CAPAN1	DNA microarray	Increased	5.2	Iacobuzio-Donahue et al. 2002
CAPAN2	DNA microarray	Increased	5.2	Iacobuzio-Donahue et al. 2002
CFPAC1	DNA microarray	Increased	5.2	Iacobuzio-Donahue et al. 2002
COLO357	DNA microarray	Increased	5.2	Iacobuzio-Donahue et al. 2002
Hs766T	DNA microarray	Increased	5.2	Iacobuzio-Donahue et al. 2002
MiaPaCa2	DNA microarray	Increased	5.2	Iacobuzio-Donahue et al. 2002
Panc-1	DNA microarray	Increased	5.2	Iacobuzio-Donahue et al. 2002
Su86.86	DNA microarray	Increased	5.2	Iacobuzio-Donahue et al. 2002
AsPc1	DNA microarray	Increased	19.6	Iacobuzio-Donahue et al. 2003
BxPc3	DNA microarray	Increased	19.6	Iacobuzio-Donahue et al. 2003
CAPAN1	DNA microarray	Increased	19.6	Iacobuzio-Donahue et al. 2003
CAPAN2	DNA microarray	Increased	19.6	Iacobuzio-Donahue et al. 2003
CFPAC1	DNA microarray	Increased	19.6	Iacobuzio-Donahue et al. 2003
Hs766T	DNA microarray	Increased	19.6	Iacobuzio-Donahue et al. 2003
MiaPaca2	DNA microarray	Increased	19.6	Iacobuzio-Donahue et al. 2003
Panc-1	DNA microarray	Increased	19.6	Iacobuzio-Donahue et al. 2003
Su86.86	DNA microarray	Increased	19.6	Iacobuzio-Donahue et al. 2003

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	ICAT	Increased	2.8	Chen et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Verma et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Iacobuzio-Donahue et al.
Invasive ductal adenocarcinoma	Western blot	Increased		Verma et al.
Invasive ductal adenocarcinoma	Label free quantitation, Mass spectrometry	Increased	4.4	Pan et al. 2011

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
Aspc-1	Western blot	Increased		Verma et al. 2006
Capan-1	Western blot	Increased		Verma et al. 2006
Capan-2	Western blot	Increased		Verma et al. 2006
MiaPaCa-2	Western blot	Increased		Verma et al. 2006
Hs-766T	Western blot	Increased		Verma et al. 2006
Panc-1	Western blot	Increased		Verma et al. 2006
Panc-02-3	Western blot	Increased		Verma et al. 2006
Panc-48	Western blot	Increased		Verma et al. 2006
Su.8686	Western blot	Increased		Verma et al. 2006

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
Protein	Label free quantitation, Mass spectrometry	Increased	2.4	Pan et al. 2011
Protein	Label free quantitation, Mass spectrometry	Increased	4.5	Pan et al. 2011

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

-

Secreted

-

Body Fluid

-

External Links

HPRD	Entrez Gene	OMIM	HGNC
01825	7052	190196	HGNC:11778

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."