Pancreatic Cancer Database

Fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)

Gene Symbol

FSCN1

Chromosome Locus

7p22

Alternate Names

SNL; Actin bundling protein, 55-KD; p55

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Intraductal papillary mucinous neoplasm with moderate dysplasia	RT-PCR	Increased		Yamaguchi et al. 2007
Intraductal papillary mucinous neoplasm with high-grade dysplasia (carcinoma in situ)	RT-PCR	Increased		Yamaguchi et al. 2007
Intraductal papillary mucinous neoplasms	DNA microarray	Increased	7.4	Sato et al. 2004
Invasive ductal adenocarcinoma	DNA microarray	Increased	5	Nakamura et al. 2004
Invasive ductal adenocarcinoma	DNA microarray	Increased	13.3	Iacobuzio-Donahue et al. 2002
Invasive ductal adenocarcinoma	DNA microarray	Increased	11	Logsdon et al. 2003
Invasive ductal adenocarcinoma	DNA microarray	Increased	3	Iacobuzio-Donahue et al. 2003

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	ICAT	Increased	2.6	Chen et al.
Intraductal papillary mucinous neoplasms	Immunohistochemistry	Increased		Yamaguchi et al.
Intraductal papillary mucinous neoplasm with an associated invasive carcinoma	Immunohistochemistry	Increased		Yamaguchi et al.
Tubular adenocarcinoma	Immunohistochemistry	Increased		Yamaguchi et al.
Colloid (mucinous noncystic) adenocarcinoma	Immunohistochemistry	Increased		Yamaguchi et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Iacobuzio-Donahue et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Lu et al.
PanIN-1A	Immunohistochemistry	Increased		Maitra et al.
PanIN-1B	Immunohistochemistry	Increased		Maitra et al.
PanIN-2	Immunohistochemistry	Increased		Maitra et al.
PanIN-3	Immunohistochemistry	Increased		Maitra et al.
PanIN-1A	Immunohistochemistry	Increased		Maitra et al.
PanIN-1B	Immunohistochemistry	Increased		Maitra et al.
PanIN-2	Immunohistochemistry	Increased		Maitra et al.
PanIN-3	Immunohistochemistry	Increased		Maitra et al.
Invasive ductal adenocarcinoma	Two dimensional electrophoresis	Increased	4	Lu et al.
Invasive ductal adenocarcinoma	Western blot	Increased	2.9	Crnogorac-Jurcevic et al.

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

Secreted

Body Fluid

External Links

HPRD	Entrez Gene	OMIM	HGNC
04068	6624	602689	HGNC:11148