Arachidonate 5-lipoxygenase
Gene Symbol   ALOX5 Chromosome Locus   10q11.2
 
  Alternate Names    
     
 
5 lipoxygenase; LOG5; 5-LO
 
   
 
  RNA Alterations     
     
 
Cancer Type
Experiment Type
Expression Level
Fold Change
PubMed ID
Invasive ductal adenocarcinoma RT-PCR
Increased
Hennig et al. 2002
Cell Line
Experiment Type
Expression Level
Fold Change
PubMed ID
MiaPaCa2 RT-PCR
Increased
Ding et al. 1999
PANC-1 RT-PCR
Increased
Ding et al. 1999
ASPC-1 RT-PCR
Increased
Ding et al. 1999
Capan2 RT-PCR
Increased
Ding et al. 1999
PANC-1 RT-PCR
Increased
Hennig et al. 2002
AsPC-1 RT-PCR
Increased
Hennig et al. 2002
MiaPaCa2 RT-PCR
Increased
Hennig et al. 2002
 
   
 
  Protein Alterations     
     
 
Cancer Type
Experiment Type
Expression Level
Fold Change
PubMed ID
Invasive ductal adenocarcinoma Immunohistochemistry
Increased
Hennig et al.
PanIN-1A Immunohistochemistry
Increased
Hennig et al.
PanIN-1B Immunohistochemistry
Increased
Hennig et al.
PanIN-2 Immunohistochemistry
Increased
Hennig et al.
PanIN-3 Immunohistochemistry
Increased
Hennig et al.
Invasive ductal adenocarcinoma Western blot
Increased
3
 Crnogorac-Jurcevic et al.
Cell Line
Experiment Type
Expression Level
Fold Change
PubMed ID
HPAF Western blot
Increased
Hennig et al. 2002
PANC-1 Western blot
Increased
Hennig et al. 2002
AsPC-1 Western blot
Increased
Hennig et al. 2002
CaPan-2 Western blot
Increased
Hennig et al. 2002
 
   
 
 Chronic Pancreatitis    
     
 
RNA/Protein
Experiment Type
Expression Level
Fold Change
PubMed ID
Protein Immunohistochemistry
Increased
Hennig et al.
Protein Immunohistochemistry
Increased
Hennig et al.
 
   
 
 
  Expressed in Body Fluid /Plasma Membrane  
     
 
     
 
Plasma Membrane -
Secreted - 
Body Fluid
-
 
   
 
   
 
  External Links     
     
 
HPRD
Entrez Gene
OMIM
HGNC
 
   
 
 
 
 

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."