Pancreatic Cancer Database

Integrin, beta 4

Gene Symbol

ITGB4

Chromosome Locus

17q25

Alternate Names

Integrin beta 4 isoform 1 precursor; Integrin beta 4 isoform 2 precursor; Integrin beta 4 isoform 3 precursor

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	SAGE	Increased		Hustinx et al. 2004
Invasive ductal adenocarcinoma	DNA microarray	Increased	34	Logsdon et al. 2003
Invasive ductal adenocarcinoma	DNA microarray	Increased	5	Crnogorac-Jurcevic et al. 2003
Invasive ductal adenocarcinoma	DNA microarray	Increased	12.5	Friess et al. 2003
Invasive ductal adenocarcinoma	DNA microarray	Increased	4.3	Laurell et al. 2006
Invasive ductal adenocarcinoma	DNA microarray	Increased	5.8	Lowe et al. 2007
PanIN-3	DNA microarray	Increased	2.2	Buchholz et al. 2005
Invasive ductal adenocarcinoma	DNA microarray	Increased	5.5	Van et al. 2012
Invasive ductal adenocarcinoma	DNA microarray	Increased	5.8	Van et al. 2012

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Logsdon et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Gleason et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Gesierich et al.
PanIN-1A	Immunohistochemistry	Increased		Cruz-Monserrate et al.
PanIN-1B	Immunohistochemistry	Increased		Cruz-Monserrate et al.
PanIN-2	Immunohistochemistry	Increased		Cruz-Monserrate et al.
PanIN-3	Immunohistochemistry	Increased		Cruz-Monserrate et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Cruz-Monserrate et al.

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
Protein	Immunohistochemistry	Increased		Gesierich et al.

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

Secreted

Body Fluid

External Links

HPRD	Entrez Gene	OMIM	HGNC
00946	3691	147557	HGNC:6158