Cyclooxygenase-2
Gene Symbol   PTGS2 Chromosome Locus   1q25.2-q25.3
 
  Alternate Names    
     
 
Prostaglandin endoperoxide synthase 2; COX2; Prostaglandin G/H synthase 2
 
   
 
  RNA Alterations     
     
 
Cancer Type
Experiment Type
Expression Level
Fold Change
PubMed ID
Pancreatic ductal adenocarcinoma RT-PCR
Increased
Xu et al.
Invasive ductal adenocarcinoma RT-PCR
Increased
11
Pham et al.
Invasive ductal adenocarcinoma RT-PCR
Increased
60
Tucker et al. 1999
Invasive ductal adenocarcinoma RT-PCR
Increased
Yada et al. 2005
Invasive ductal adenocarcinoma RT-PCR
Increased
Okami et al. 1999
Microcystic serous cystadenoma RT-PCR
Increased
Okami et al. 1999
Invasive ductal adenocarcinoma In situ hybridization
Increased
Niijima et al. 2002
Intraductal papillary mucinous neoplasm with an associated invasive carcinoma In situ hybridization
Increased
Niijima et al. 2002
Intraductal papillary mucinous neoplasm with low-grade dysplasia In situ hybridization
Increased
Niijima et al. 2002
Intraductal papillary m In situ hybridization
Increased
Niijima et al. 2002
Cell Line
Experiment Type
Expression Level
Fold Change
PubMed ID
Panc-1 RT-PCR
Increased
Xu et al.
BxPC3 RT-PCR
Increased
Okami et al. 1999
PCI6 RT-PCR
Increased
Okami et al. 1999
PSN1 RT-PCR
Increased
Okami et al. 1999
T3M4 RT-PCR
Increased
Yada et al. 2005
BxPC3 RT-PCR
Increased
Yada et al. 2005
 
   
 
  Protein Alterations     
     
 
Cancer Type
Experiment Type
Expression Level
Fold Change
PubMed ID
Pancreatic ductal adenocarcinoma Immunohistochemistry
Increased
Xu et al.
Pancreatic ductal adenocarcinoma Immunoblot
Increased
Xu et al.
Invasive ductal adenocarcinoma Western blot
Increased
Pham et al.
Pancreatic ductal adenocarcinoma, PanIN Immunohistochemistry
Increased
Matsubayashi et al.
Invasive ductal adenocarcinoma ELISA
Increased
Tjomsland et al.
Endocrine Neoplasms Immunohistochemistry
Increased
Ohike et al.
Intraductal papillary mucinous neoplasm with an associated invasive carcinoma Immunohistochemistry
Increased
Kokawa et al.
Invasive ductal adenocarcinoma Immunohistochemistry
Increased
Kokawa et al.
Invasive ductal adenocarcinoma Immunohistochemistry
Increased
Tucker et al.
Invasive ductal adenocarcinoma Immunohistochemistry
Increased
Wang et al.
Invasive ductal adenocarcinoma Immunohistochemistry
Increased
Okami et al.
Adenosquamous carcinoma Immunohistochemistry
Increased
Okami et al.
Microcystic serous cystadenoma Immunohistochemistry
Increased
Okami et al.
Invasive ductal adenocarcinoma Immunohistochemistry
Increased
Albazaz et al.
PanIN-2 Immunohistochemistry
Increased
Albazaz et al.
PanIN-3 Immunohistochemistry
Increased
Albazaz et al.
PanIN-1A Immunohistochemistry
Increased
Albazaz et al.
PanIN-1B Immunohistochemistry
Increased
Albazaz et al.
PanIN-2 Immunohistochemistry
Increased
Albazaz et al.
PanIN-3 Immunohistochemistry
Increased
Albazaz et al.
Invasive ductal adenocarcinoma Immunohistochemistry
Increased
Niijima et al.
Intraductal papillary mucinous neoplasm with an associated invasive carcinoma Immunohistochemistry
Increased
Niijima et al.
Intraductal papillary mucinous neoplasm with low-grade dysplasia Immunohistochemistry
Increased
Niijima et al.
Intraductal papillary m Immunohistochemistry
Increased
Niijima et al.
Invasive ductal adenocarcinoma Western blot
Increased
Okami et al.
Invasive ductal adenocarcinoma Western blot
Increased
Franco et al.
Invasive ductal adenocarcinoma Western blot
Increased
Tucker et al.
Invasive ductal adenocarcinoma Western blot
Increased
Schlosser et al.
Cell Line
Experiment Type
Expression Level
Fold Change
PubMed ID
Panc-1 Immunohistochemistry
Increased
Xu et al.
MIAPaCa-2 Immunohistochemistry
Increased
Kokawa et al. 2001
Panc-1 Immunohistochemistry
Increased
Kokawa et al. 2001
 
   
 
 Chronic Pancreatitis    
     
 
RNA/Protein
Experiment Type
Expression Level
Fold Change
PubMed ID
Protein Immunohistochemistry
Increased
Schlosser et al.
Protein Western blot
Increased
Schlosser et al.
 
   
 
 
  Expressed in Body Fluid /Plasma Membrane  
     
 
     
 
Plasma Membrane -
Secreted
Body Fluid
-
 
   
 
   
 
  External Links     
     
 
HPRD
Entrez Gene
OMIM
HGNC
 
   
 
 
 
 

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."