Pancreatic Cancer Database

Aurora kinase A

Gene Symbol

AURKA

Chromosome Locus

20q13.2-q13.3

Alternate Names

AIK; ARK1; AURA

RNA Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Intraductal papillary mucinous neoplasms	DNA microarray	Increased	5.2	Sato et al. 2004
Invasive ductal adenocarcinoma	RT-PCR	Increased		Rojanala et al. 2004
Invasive ductal adenocarcinoma	DNA microarray	Increased	5.4	Iacobuzio-Donahue et al. 2003
Invasive ductal adenocarcinoma	DNA microarray	Increased	4.4	Grutzmann et al. 2004
Mucinous cystic neoplasms	DNA microarray	Increased	6.5	Fukushima et al. 2004
PanIN-2	DNA microarray	Increased	2.3	Buchholz et al. 2005
PanIN-3	DNA microarray	Increased	3.2	Buchholz et al. 2005
PanIN-3	DNA microarray	Increased	3.2	Buchholz et al. 2005

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
HS-766T	Northern blot	Increased	5	Li et al. 2003
MIAPaCa-2	Northern blot	Increased	5	Li et al. 2003
Panc-1	Northern blot	Increased	5	Li et al. 2003
Panc-3	Northern blot	Increased	5	Li et al. 2003
Panc-28	Northern blot	Increased	5	Li et al. 2003
Panc-48	Northern blot	Increased	5	Li et al. 2003
HPAF 11	Northern blot	Increased	5	Li et al. 2003
Aspc-1	Northern blot	Increased	5	Li et al. 2003
Bxpc-3	Northern blot	Increased	5	Li et al. 2003
AsPc1	DNA microarray	Increased	10.8	Iacobuzio-Donahue et al. 2003
BxPc3	DNA microarray	Increased	10.8	Iacobuzio-Donahue et al. 2003
CAPAN1	DNA microarray	Increased	10.8	Iacobuzio-Donahue et al. 2003
CAPAN2	DNA microarray	Increased	10.8	Iacobuzio-Donahue et al. 2003
CFPAC1	DNA microarray	Increased	10.8	Iacobuzio-Donahue et al. 2003
Hs766T	DNA microarray	Increased	10.8	Iacobuzio-Donahue et al. 2003
MiaPaca2	DNA microarray	Increased	10.8	Iacobuzio-Donahue et al. 2003
Panc-1	DNA microarray	Increased	10.8	Iacobuzio-Donahue et al. 2003
Su86.86	DNA microarray	Increased	10.8	Iacobuzio-Donahue et al. 2003

Protein Alterations

Cancer Type	Experiment Type	Expression Level	Fold Change	PubMed ID
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Rojanala et al.
Invasive ductal adenocarcinoma	Immunohistochemistry	Increased		Li et al.
Invasive ductal adenocarcinoma	Western blot	Increased	10	Li et al.

Cell Line	Experiment Type	Expression Level	Fold Change	PubMed ID
AsPC-1	Western blot	Increased		Rojanala et al. 2004
BxPC-3	Western blot	Increased		Rojanala et al. 2004
Capan-1	Western blot	Increased		Rojanala et al. 2004
CFPAC-1	Western blot	Increased		Rojanala et al. 2004
HPAF II	Western blot	Increased		Rojanala et al. 2004
Mia PaCa-2	Western blot	Increased		Rojanala et al. 2004
Mutj	Western blot	Increased		Rojanala et al. 2004
Panc-1	Western blot	Increased		Rojanala et al. 2004
SU.86.86	Western blot	Increased		Rojanala et al. 2004
HS-766T	Western blot	Increased	1.5	Li et al. 2003
MIAPaCa-2	Western blot	Increased	1.5	Li et al. 2003
Panc-1	Western blot	Increased	1.5	Li et al. 2003
Panc-3	Western blot	Increased	1.5	Li et al. 2003
Panc-28	Western blot	Increased	1.5	Li et al. 2003
Panc-48	Western blot	Increased	1.5	Li et al. 2003
HPAF 11	Western blot	Increased	1.5	Li et al. 2003
Aspc-1	Western blot	Increased	1.5	Li et al. 2003
Bxpc-3	Western blot	Increased	1.5	Li et al. 2003

Chronic Pancreatitis

RNA/Protein	Experiment Type	Expression Level	Fold Change	PubMed ID
No Data

Expressed in Body Fluid /Plasma Membrane

Plasma Membrane

-

Secreted

-

Body Fluid

-

External Links

HPRD	Entrez Gene	OMIM	HGNC
04066	6790	603072	HGNC:11393

Pancreatic Cancer Database was funded by the "Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins."